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个人简介

1999-2003 北京大学化学与分子工程学院 学士 2003-2008 北京大学化学与分子工程学院 博士 2008-2015 University of Pennsylvania 博士后 2015-2018 清华大学生命科学学院 助理教授 2018-至今 清华大学生命科学学院 副教授

研究领域

发展新型单分子荧光技术 蛋白在DNA上的靶向搜寻机制的研究 CRISPR系列蛋白靶向和剪切机制的研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Yuan Zhang (#), Chen Yang (#), Sijia Peng, Jing Ling, Peng Chen, Yumiao Ma, Wenjuan Wang, Zhixing Chen (*), Chunlai Chen (*), (2023) General strategy to improve the photon budget of thiol-conjugated cyanine dyes, Journal of the American Chemical Society, 145, 7, 4187-4198 Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W Hildebrand, Chunlai Chen (*), Brian K. Kobilka (*), (2023) Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor, Nat Commun, Accepted Yirong Yao, Wenjuan Wang, Chunlai Chen (*), (2022) Mechanisms of phase-separation-induced cGAS activation revealed by dcFCCS, PNAS Nexus, doi.org/10.1093/pnasnexus/pgac109 Jingfei Xu(#), Lingyun Zhao(#), Sijia Peng(#), Huiying Chu(#), Rui Liang, Meng Tian, Philip P. Connell, Guohui Li (*), Chunlai Chen (*) and Hong-Wei Wang (*), (2021) Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination, Nucleic Acids Research, 49, 13135-13149 Xiaolin Niu(#), Ruirui Sun(#), Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen (*) and Xianyang Fang (*), (2021) Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs, Nat Commun, 12, 6417 Mengyi Yang, Ruirui Sun, Pujuan Deng, Yuzhuo Yang, Wenjuan Wang, Jun-Jie Gogo Liu (*) and Chunlai Chen (*), (2021) Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search, Chem Sci, 12, 12776-12784 Victor Pan, Wen Wang, Ian Heaven, Tanxi Bai, Yongxin Cheng, Chunlai Chen (*), Yonggang Ke (*) and Bryan Wei (*), (2021) Monochromatic Fluorescent Barcodes Hierarchically Assembled from Modular DNA Origami Nanorods, ACS Nano, 15, 15892–15901 Ming-Jie Han(#), Qing-tao He(#), Mengyi Yang(#), Chao Chen, Yirong Yao, Xiaohong Liu, Yuchuan Wang, Zhong-liang Zhu, Kong-kai Zhu, Changxiu Qu, Fan Yang, Cheng Hu, Xuzhen Guo, Dawei Zhang, Chunlai Chen (*), Jin-peng Sun (*) and Jiangyun Wang (*), (2021) Single-molecule FRET and conformational analysis of beta-arrestin-1 through genetic code expansion and a Se-click reaction, Chem Sci, 12, 9114-9123 Sijia Peng (#), Weiping Li (#), Yirong Yao (#), Wenjing Xing, Pilong Li (*) and Chunlai Chen (*), (2020) Phase separation at the nanoscale quantified by dcFCCS, PNAS, 117(44):27124-27131 Sijia Peng (#), Xiaowei Wang (#), Lu Zhang (#)(*), Shanshan He, Xin Sheng Zhao (*), Xuhui Huang (*) and Chunlai Chen (*), (2020) Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models, PNAS, 117(36):21889-21895 Lujia Zhang, Ruirui Sun, Mengyi Yang, Sijia Peng, Yongxin Cheng, and Chunlai Chen (*), (2019) Conformational dynamics and cleavage sites of Cas12a are modulated by complementarity between crRNA and DNA, iScience, 19:492-503 Man Pan (#), Qingyun Zheng (#), Shan Ding (#), Lujia Zhang (#), Qian Qu, Tian Wang, Danning Hong, Yunjing Ren, Lujun Liang, Chunlai Chen (*), Ziqing Mei (*), and Lei Liu (*), (2019) Chemical Protein Synthesis-Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains, Angew. Chem. Int. Ed, 58(9):2627-2631 Bo Wu, Haibo Zhang, Ruirui Sun, Sijia Peng, Barry S Cooperman, Yale E Goldman (*), and Chunlai Chen (*), (2018) Translocation kinetics and structural dynamics of ribosomes are modulated by the conformational plasticity of downstream pseudoknots, Nucleic Acids Research, 46(18): 9736-9748 Mengyi Yang(#), Sijia Peng(#), Ruirui Sun, Jingdi Lin, Nan Wang, and Chunlai Chen(*), (2018) The Conformational Dynamics of Cas9 Governing DNA Cleavage Are Revealed by Single-Molecule FRET, Cell Reports, 22(2): 372-382 Sijia Peng, Ruirui Sun, Wenjuan Wang and Chunlai Chen(*), (2017) Single-Molecule Photoactivation FRET: A General and Easy-to-Implement Approach to Break the Concentration Barrier, Angew. Chem. Int. Ed, 56(24):6882-6885

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