Kohane, Daniel S. - Harvard Medical School - Laboratory for Biomaterials and Drug Delivery

个人简介

Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Boston Children's Hospital) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Boston Children's Hospital). He is currently a Senior Associate in Pediatric Critical Care at Boston Children's Hospital at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery. He is also a senior associate in the laboratory of Prof. Robert Langer at the Massachusetts Institute of Technology. Focus of Research: Our research focuses on a wide range of medical problems including pain, peritoneal and other adhesions, surgical glues, vaccine vehicles, intracranial drug delivery, intra-articular drug delivery, patient-controlled drug delivery systems, antifungal surfaces, intracellular delivery of enzymes, ocular and trans-tympanic drug delivery, corneal prostheses, and others. We have employed microparticles and nanoparticles, including polymer systems, liposomes, mesoporous silicates, and others; hydrogels; and combination systems. Other interests include microfluidics, tissue engineering, and surface modification. We have applied our approach in food, beverage, and agricultural research as well. Translational Research: Most of our research is very oriented toward clinical application.

研究领域

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The unifying theme in our research is drug delivery and biomaterials. In this multidisciplinary field, the specific application is less important than the development of an approach or set of approaches. The skilled practitioner applies engineering principles, biology, and knowledge of biomaterials to achieve a given goal. While addressing specific disease states is important, the thrust of research is to create methods by which drugs can be delivered to a range of sites in a variety of circumstances, or by which materials can be developed or adapted for biomedical uses.