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个人简介

教育背景 1978 - 1982 年,宁夏大学化学系,化学专业,本科,成绩名列前茅 1984 - 1986 年,中国科学院,化学专业,硕士 1990 - 1995 年,美国阿拉巴马大学伯明翰分校,生物化学专业,博士 工作经历 1987 - 1990 年,美国国立卫生研究院,访问学者 1995 - 2002 年,美国麻省理工学院生物学系,博士后 1997 - 2002 年,美国哈佛大学医学院贝斯以色列女执事医疗中心,研究助理 2002 - 2010 年,美国华盛顿大学圣路易斯分校,病理学与免疫学系,助理教授 2010 年 - 至今,中国海洋大学医药学院,转化医学筑峰教授 2011 年 - 至今,山东省泰山学者 获奖荣誉 1978 - 1982 年,宁夏大学优秀本科生 1984 - 1985 年,中国科学院优秀研究生 1994 - 1995 年,美国阿拉巴马大学伯明翰分校 John M. McKibbin 学者 1997 - 2000 年,美国国立卫生研究院国家研究服务奖 2004 - 2010 年,美国国立卫生研究院 RO1 奖 2007 - 2009 年,圣路易斯儿童发现研究所研究奖 2011 年 - 至今,国家自然科学基金研究奖

研究领域

基于细胞和动物研究糖胺聚糖(GAGs)的生物合成、结构和功能调控 发现基于 GAGs 的癌症和衰老相关疾病的生物标志物 研究 GAGs 在癌症和免疫系统调节中的作用 探究 GAGs 相关药物的分子基础

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Wu L., Zhang, L., Yabe, T., Beeler, D. L., Love, A., and Rosenberg, R. D. (2003) The Involvement of Heparan Sulfate in FGF1/HS/FGFR1 Signaling Complex. J Biol Chem.278(19):17121-29. PMID: 12604602(SCI, 5.498) 2. Griffith, C. L., Klutts, J. S., Zhang, L., Levery, S. B. & Doering, T. L. (2004) UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus Neoformans. J Biol Chem 279, 51669-76. PMID: 15383535 (SCI, 5.498) 3. Broekelmann T.J., Kozel B.A., Ishibashi, H., Werneck C.C., Keeley F.W., Zhang L., and Mecham R.P. (2005) Tropoelastin Interacts with Cell-Surface Glycosaminoglycans Via Its COOH-Terminal Domain. J Biol Chem 280: 40939-40947. PMID: 16192266 (SCI, 5.498) 4. Chen J., Avci F.Y., Munoz E.M., McDowell L.M., Chen M., Pedersen L.C., Zhang L., Linhardt R.J., and Liu J. (2005) Enzymatic Redesigning of Biologically Active Heparan Sulfate. J Biol Chem 280: 42817-42825. PMID: 16260789 (SCI, 5.498) 5. Studelska D.R., Giljum, K., McDowell L.M., and Zhang L. (2006) Quantification of Glycosaminoglycans by Reversed-Phase HPLC Separation of Fluorescent Isoindole Derivatives.Glycobiology 16: 65-72. PMID: 16166601 (SCI, 4.268) 6. McDowell L.M., Frazier B.A., Studelska D.R., GIljum K., Chen J., Liu J., Yu K., Ornitz D.M., and Zhang L. (2006) Inhibition or Activation of Apert Syndrome FGFR2 (S252W) Signaling by Specific Glycosamininoglycans. J Biol Chem. 281:6924-30. PMID: 16373332 (SCI, 5.498) 7. Halldorsdottir A.M., Zhang L. & Tollefsen D.M. (2006) N-Acetylgalactosamine 4, 6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate.Glycobiology, 16, 693. PMID: 16624894 (SCI, 4.268) 8. Avirutnan P., Zhang L., PunyadeeN., ManuyakornA., PuttikhuntC., KasinrerkW., Malasit P., Atkinson J.P., & Diamond M.S. (2007) Secreted Non-Structural Protein NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E.PLOS Pathogens11(3):e183. PMID: 18052531 (SCI, 9.675) 9. Lawrence R., Lu H., Rosenberg R.D., Esko J.D., & Zhang L. (2008) Disaccharide Structure Code for the easy representation of constituent oligosaccharides from glycosaminoglycans. Nature Method 5(4):291-2. PMID: 18376390 (SCI, 27.887) 10. Kemper C., Mitchell L.M., Zhang L. and Hourcade D.E. The Complement Protein Properdin is a Pattern-recognition Molecule that Mediates Uptake of Apoptotic T Cells. (2008) PNAS(SCI, 9.771) 105(26):9023-8. PMID:18579773 11. Liszewski, M.K., Bertram, P., Leung, M.K., Hauhart, R., Zhang, L., and Atkinson, J.P. Smallpox inhibitor of complement enzymes (SPICE): Regulation of Complement Activation on Cells and Mechanism of Its Cellular Attachment. (2008) J Immunol181(6):1499-207. PMID: 18768877(SCI, 5.909) 12. de Agostini A.I., Dong J., Arrighi C., Ramus M., Dentand-Quadri, Thalmann S., Ventura P., Ibecheole V., Monge F., Fischer A., HajMohammadi S., Shworak N.W., Zhang L., Zhang Z., Linhardt R.J. (2008) Human Follicular Fluid Heparan Sulfate Contains Abundant 3-O-sulfated Chains with Anticoagulant Activity. J Biol Chem 283(42):28115-24. PMID: 18669628 (SCI, 5.498) 13. Studelska D.R., Mandik-Nayak L., Zhou, X., Pan, J., McDowell L.M., Lu H., Liapis, H., Allen P.M., Shih F., & Zhang L (2009). High Affinity Glycosaminoglycan and Autoantigen Interaction Explains Joint Specificity in a Mouse Model of Rheumatoid Arthritis. J Biol Chem(SCI, 5.498). 284(4):2354-62. PMID: 18948258 14. Dündar, M., Müller, T., Zhang, Q., Pan, J., Steinmann, B., Vodopiutz, J., Gruber, R., Tonoda, S., Krabichler, B., Utermann, G., Baenziger, J. U., Zhang, L. and Janecke, A. R. (2009) Loss of dermatan-4-sulfotransferase-1 function results in ‘adducted thumb-clubfoot syndrome’ (ATCS).Am J Hum Genet. 85(6): 873-82. PMID: 20004762(SCI, 12.265) 15. Snyder-Warwick, A.A., Perlyn, C.A., Pan, J., Yu, K., Zhang, L., Ornitz, D.M.A gain-of-function FGFR2 Crouzon mutation: evidence of loss-of-function activity in the etiology of cleft palate. (2010) PNAS 107:2515-2520. PMID: 20133659(SCI, 9.771) 16. Pan, J., Qian, Y., Zhou, X., Pazandak, A., Frazier, S. B., Weiser, P., Lu, H. and Zhang, L. (2010) Oversulfated Chondroitin sulfate is not the Sole Contaminant in Heparin Nature Biotechnology 208:203-207. PMID: 20212477(SCI, 29.061) 17. Pan, J., Qi, Y., Zhou, X., Lu, H. and Zhang, L. (2010) Chemically Oversulfated Glycosaminoglycans Are Potent Modulators of Contact System Activation and Cell Signaling. J Biol Chem285(30):22966-22975. PMID: 20418371 (SCI, 5.498) 18. Zhang, L*., Lawrence, R., Frazier, B.A. & Esko, J.D. (2006) Methods in Enzymology, Volume 416, Chapter 13. Elservier Inc., San Diego. *Correspondence Author, reported new CHO cell mutants developed and characterized in Zhang lab. PMID: 17113868 (SCI, Book) 19. Zhang, L., Glycosaminoglycan (GAG) biosynthesis and GAG-binding proteins (2010) Prog Mol Biol Transl Sci. Glycosaminoglycans in Development, Health, and Diseases, Zhang, L. Editor. Elsevier Inc., p. 2-17. PMID:20807638 (SCI, Book) 20. Zhang, L., Müller, T., Baenzige,r J.U., Janecke, A. (2010) Adducted thumb-clubfoot syndrome (ACTS) and loss of dermatan-4-sulfotransferase 1 (D4ST1) function. Prog Mol Biol Transl Sci. Glycosaminoglycans in Development, Health, and Diseases, Zhang, L., Editor. Elsevier Inc., p. 289-308. PMID:20807649 (SCI, Book) 21. Qian, Y., Pan, J., Zhou, X., Weiser, P., Lu, H., and Zhang, L. (2010)Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis. Prog Mol Biol Transl Sci.Glycosaminoglycans in Development, Health, and Diseases, Zhang, L., Editor. Elsevier Inc., p. 395-421. PMID:20807654 (SCI, Book) 22. Zhou, X., Weiser, P., Pan, J., Qian, Y., Lu, H., and Zhang, L. (2010)Chondroitin Sulfate and Abnormal Contact System in Rheumatoid Arthritis.Prog Mol Biol Transl Sci. Glycosaminoglycans in Development, Health, and Diseases, Zhang, L. Editor. Elsevier Inc., p. 423-442. PMID:20807655 (SCI, Book) 23. Weiser, P., Qian, Y., Pan, J., Zhou, X., Lu, H., Studelska, D.R., Shih, F.F., and Zhang, L.(2010) Activated Contact System and Abnormal Glycosaminoglycans in Lupus and other Auto- and Non-autoimmune Diseases. Prog Mol Biol Transl Sci. Glycosaminoglycans in Development, Health, and Diseases, Zhang, L. Editor. Elsevier Inc., p. 443-472. PMID:20807656 (SCI, Book) 24. Pan, J., Qian, Y., Weiser, P., Zhou, X., Lu, H., Studelska, D.R., and Zhang, L.(2010)Glycosaminoglycans and Activated Contact System in Cancer Patient Plasmas. Prog Mol Biol Transl Sci. Glycosaminoglycans in Development, Health, and Diseases, Zhang, L. Editor. Elsevier Inc., p. 473-496. PMID:20807657 (SCI, Book) 25. Kanekiyo, T., Zhang, J., Liu, Q., Liu, C.C., Zhang, L., Bu, G. Heparan Sulphate Proteoglycan and the Low-density Lipoprotein Receptor-related Protein 1 Constitute Major Pathways for Neuronal Amyloid-beta Uptake.J Neurosci. 31(5):1644-51. PMID: 289173 (SCI, 8.068) 26. Kaur, S., Kuznetsova, S.A., Pendrak, M.L., Sipes, J.M., Romeo, M.J., Li, Z., Zhang, L., Roberts DD. Identification of CD47 and Amyloid Precursor-like Protein-2 as the Major Heparan Sulfate Proteoglycans on T Lymphocytes and this Isoform of CD47 as the Signaling Receptor for Thrombospondin-1.J Biol Chem 286(17):14991-5002. PMID: 21343308 (SCI, 5.498)

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