个人简介
Xiao was born and raised in Linyi, Shandong, China. He received his B.S. degree in Applied Chemistry from Shandong Normal University (2008) in Jinan, Shandong, where he was mentored by Prof. Qingjian Liu (刘庆俭教授). After moving to Shanghai, he completed his Ph.D. at Shanghai Institute of Organic Chemistry (2013) with Prof. Jinbo Hu (胡金波研究员). After a half year stay as a research associate at SIOC, he moved to Boston for postdoctoral studies with Prof. Tobias Ritter at Harvard University and Prof. Amir H. Hoveyda at Boston College. In August 2017, Xiao accepted an appointment at Wuhan University, where he is a professor in the Institute for Advanced Studies.
EDUCATION AND RESEARCH EXPERIENCE
Professor 08/2017 The Institute for Advanced Studies, Wuhan University, Wuhan, China
Post-Doctoral Associate 06/2015−07/2017 Department of Chemistry, Merkert Chemistry Center, Boston College, MA, USA Advisor: Prof. Amir H. Hoveyda
Post-Doctoral Fellow 02/2014−05/2015 Department of Chemistry and Chemical Biology, Harvard University, MA, USA Advisor: Prof. Tobias Ritter
Research Associate 07/2013−02/2014 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China. Advisor: Prof. Jinbo Hu
Ph.D. Organic Chemistry 2013 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China Advisor: Prof. Jinbo Hu
B. S. Chemistry 2008 Shandong Normal University, Jinan, P. R. China
近期论文
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X. He, Y. Zhang, S. Liu, W. Zhang, Z. Liu, Y. Zhao, X. Shen*. "Photocatalytic Site-Selective Radical C(Sp3)–H Aminoalkylation, Alkylation and Arylation of Silanes." Nat. Synth. 2024, DOI: https://doi.org/10.1038/s44160-024-00664-9.
Z. Li#, Z. Zhang#, Z. Zhang#, Y. Zhang, S. Liu*, X. Shen*. "Visible-Light-Induced Organocatalyzed C(sp2)-H Bond Functionalization of 1,3-Azoles with Trifluoroacetylsilanes. '' Sci. China Chem. 2024, DOI: https://doi.org/10.1007/s11426-024-2203-5.
Y. Liu, Z. Zhu, Y. Zhang, Y. Zhang, S. Liu*, X. Shen*. "Stereoselective Synthesis of Silyl Enol Ethers with Acylsilanes and α,β-Unsaturated Ketones." Org. Lett. 2024. DOI: https://doi.org/10.1021/acs.orglett.4c01782.
Y. Zhang, X. Shen*. ''Photothermal cascade metathesis and cyclization.'' Trends Chem. 2024, 6, 5, 274-275.
G. Zhou#, Z. Guo#, S. Liu, X. Shen*. ''Divergent Synthesis of Fluoroalkyl Ketones through Controlling the Reactivity of Organoboronate Complexes.'' J. Am. Chem. Soc. 2024, ASAP, https://doi.org/10.1021/jacs.3c12150.
S. Deng, C. Peng, Y. Niu, Y. Xu, Y. Zhang, X. Chen, H. Wang, S. Liu, X. Shen*. ''Radical Brook Rearrangement Mediated Olefin Difunctionalization with α-Fluoroalkyl-α-silyl Methanols.'' Acta Chim. Sinica 2023, DOI: 10.6023/A23110487.
Y. Zhang, J. Wang, Y. Guo, S. Liu, X. Shen*. "Carbonyl Olefin Metathesis and Dehydrogenative Cyclization of Aromatic Ketones and gem-Difluoroalkenes." Angew. Chem. Int. Ed. 2023, e202315269.
Y. Guo, G. Zhou, X. Shen*. "Synthesis of organofluorine compounds with acylsilanes." Chin. J. Chem. 2023, DOI: 10.1002/cjoc.202300569.
Z. Li#, X. Chen#, C. Peng, Y. Xu, H. Wang, S. Liu, X. Shen*. ''Merging Radical Brook Rearrangement and 1,5-Hydrogen Atom Transfer: Facile Synthesis of Ketone-Containing ɑ-Fluoroalkyl Alcohols.'' ChemCatChem 2023, e202301075.
C. Jin#, X. He#, S. Chen, Z. Guo, Y. Lan*, X. Shen*. "Axial Chirality Reversal and Enantioselective Access to Si-stereogenic Silylallene" Chem 2023, 9, 2956-2970.
S. Chen, Y. Zhang, S. Liu, X. Shen*. ''Photocatalyzed [2+1] Cyclization of Alkenes and Silylated Trifluorodiazoethanes: Facile Entry into (Difluoromethylene)cyclopropanes'' Sci. China Chem 2023, 66, 3141–3147.
Z. Li, Y. Zhang, Y. Zhang, X. He, X. Shen*. "Diastereoselective Synthesis of Monofluorocyclohexenes through Photocatalyzed Cascade Cyclization of gem-Difluoroalkenes and α,β-Unsaturated Carbonyl Compounds" Angew. Chem. Int. Ed. DOI: https://doi.org/10.1002/anie.202303218.
G. Zhou#, Z. Guo#, X. Shen*. "Electron-Rich Oxycarbenes: New Synthetic and Catalytic Applications beyond Group 6 Fischer Carbene Complexes" Angew. Chem. Int. Ed. 2023, 62, e202217189.
Y. Zhang#, Y. Zhang#, C. Ye, X. Qi*, L.-Z. Wu*, X. Shen*. ''Cascade cyclization of alkene-tethered acylsilanes and allylic sulfones enabled by unproductive energy transfer photocatalysis'' Nat. Commun. 2022, 13, 6111.
S. Chen, X. He, C. Jin, W. Zhang, Y. Yang, S. Liu, Y. Lan*, K. N. Houk*, X. Shen*. "Nickel-Catalyzed Cross-Redistribution between Hydrosilanes and Silacyclobutanes" Angew. Chem. Int. Ed. 2022, 61, e202213431.
Y. Zhang#, Y. Niu#, Y. Guo, J. Wang, Y. Zhang, S. Liu, X. Shen*. "Photocatalyzed Cascade Reactions of Cyclopropanols and α-Trifluoromethyl-Substituted Olefins for the Synthesis of Fused gem-Difluorooxetanes" Angew. Chem. Int. Ed. DOI: 10.1002/anie.202212201.
P. Jin, X. Shen*. "SulfoxFluor as a deoxyfluorination reagent, and beyond" J. Fluorine Chem. 2022, 261-262: 110029.
Z. Zhu, W. Zhang, Y. Zhang, S. Liu, and X. Shen.*''Visible-Light-Induced [4+1] Cyclization-Aromatization of Acylsilanes and ɑ, β-Unsaturated Ketones'' CCS Chemistry. 2022, DOI: 10.31635/ccschem.022.202202199.
S. Chen, X. He, Y. Jin, Y. Lan,* X. Shen.* ''Copper-Catalyzed Regio- and Stereo-Selective Hydrosilylation of Terminal Allenes to Access (E)-Allylsilanes'' Nat. Commun, 2022, 13 (1): 3691.
G. Zhou, X. Shen.* '' Visible-Light-Induced Organocatalyzed [2+1] Cyclization of Alkynes and (Trifluoroacetyl)silanes'' Synlett 2022, DOI: 10.1055/a-1840-5199. (Invited Synpacts).
Y. Zhang, # G. Zhou, # X. Gong, # Z. Guo, X. Qi, * X. Shen.* ''Diastereoselective Transfer of Tri(di)fluoroacetylsilanes-Derived Carbenes to Alkenes'' Angew. Chem. Int. Ed. 2022, 61, e202202175.
Y. Zhang, Y. Zhang, Y. Guo, S. Liu, X. Shen.* ''Reductive Quenching-Initiated Catalyst-Controlled Divergent Alkylation of α-CF3-Olefin'' Chem Catal. 2022, accepted.
X. He, Y. Zhao, Z. Zhang, X. Shen.* “Tuning the Reactivity of Alkoxyl Radicals from Cyclization to 1,2-Silyl Transfer: Stereoselective Synthesis of β-Substituted Cycloalcohols” Org. Lett. 2022, 24, 1991-1995.
X. Fang, # W. Wen, # P. Jin, W. Bao, S. Liu, H. Cong, X. Shen.* '' Synthesis of Enantioenriched Fluorinated Enol Silanes Enabled by Asymmetric Reductive Coupling of Fluoroalkylacylsilanes and 1,3-Enynes and Brook Rearrangement'' Acs Catal. 2022, 12, 2150-2157.
G. Zhou, X. Shen.* ''Synthesis of Cyclopropenols Enabled by Visible-Light-Induced Organocatalyzed [2+1] Cyclization'' Angew. Chem. Int. Ed. 2022, 61, e202115334.
X. Chen, Z. Zhu, S. Liu, Y.-H. Chen, X. Shen.* '' MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction.'' Chin. Chem. Lett. 2021, accepted. https://doi.org/10.1016/j.cclet.2021.10.083. (Invited contribution to the special collection on “Fluorine Chemistry”.)
Z. Zhu, X. Chen, S. Liu, J. Zhang, X. Shen.* '' Synthesis of 1-Tri(di)fluoromethyl 1,4-Diketones Enabled by Radical Brook Rearrangement.'' Eur. J. Org. Chem. 2021, 4927.
Y. Zhang, Y. Zhang, X. Shen.* ''Alkoxyl Radical-Mediated Synthesis of Functionalized Allyl tert-(Hetero)cyclobutanols and Their Ring-opening and Ring-expansion Functionalizations.'' Chem Catal. 2021, 1(2), 423.
Z. Yang#, Y. Niu# , X. He, S. Chen, S. Liu, Z. Li, X. Chen, Y. Zhang, Y. Lan*, X. Shen.* ''Tuning the Reactivity of Alkoxyl Radicals from 1,5-Hydrogen Atom Transfer to 1,2-Silyl Transfer'' Nat. Commun. 2021, 12, 2131.
X. Chen#, X. Gong#, Z. Li, G. Zhou, Z. Zhu, W. Zhang, S. Liu, X. Shen.* "Direct transfer of tri- and di-fluoroethanol units enabled by radical activation of organosilicon reagents" Nat. Commun. 2020, 11, 2756.
Y. Zhang#, Y. Chen#, Z. Zhang, S. Liu, X. Shen.* “Synthesis of Stereodefined Trisubstituted Alkenyl Silanes Enabled by Borane Catalysis and Nickel Catalysis” Org. Lett 2020, 3, 970-975.
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