Reckseidler-Zenteno, Shauna - Athabasca University

个人简介

B.Sc. in Cellular, Molecular, and Microbial Biology Department of Biological Sciences University of Calgary, Calgary, Alberta, CanadaPh.D. in Microbiology and Infectious Diseases Faculty of Medicine University of Calgary, Calgary, Alberta, CanadaPost-doctoral fellowships in Microbiology and Infectious Diseases and Surgery Faculty of Medicine University of Calgary, Calgary, Alberta, Canada

研究领域

I am working on developing graduate courses in Research Methods, Bioremediation, Biofilms, and Environmental Health for our proposed MSc in Environmental Science. I would like to develop courses in Molecular Genetics and Bacterial Pathogenesis in the future. I am active in supervision of undergraduate students in research project courses.In the past my research was focused on understanding how the bacterial pathogen, Burkholderia pseudomallei, causes disease. B. pseudomallei is a bacteria that lives in the soil and water in tropical regions of the world. It is the causative agent of the disease melioidosis, which affects both humans and animals primarily in Southeast Asia and northern Australia. My current research is focused on a related bacterial pathogen, Pseudomonas aeruginosa. P. aeruginosa is a gram-negative bacterium that is ubiquitous in the environment and able to cause disease in plants, animals, and humans. This diverse organism is a common cause of nosocomial or hospital-acquired infections, most notably causing skin infections in burn patients, infections of indwelling devices such as catheters, and fatal lung infections in patients with cystic fibrosis. Studies have shown that P. aeruginosa may survive for months on hospital surfaces and can be isolated from the water in intensive care units. We are interested in understanding how P. aeruginosa is able to survive in the environment, particularly in water. The ability of the organism to persist at length in water make it a resevoir for infectious disease. We have also been testing synthetic antimicrobial peptides for efficacy against biofilms produced by the bacterial pathogens P. aeruginosa and Klebsiella pneumoniae using the BioFlux system that we house in the laboratory in Athabasca. This work is in collaboration with the laboratory of Dr. Bob Hancock at the University of British ColumbiaI currently hold an Adjunct Faculty appointment at the University of Calgary and have lab space in both Calgary and Athabasca.

近期论文

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Reckseidler, S. L., DeShazer, D., Sokol, P. A., and Woods, D. E. (2001). Detection of Bacterial Virulence Genes by Subtractive Hybridization: Identification of the Capsular Polysaccharide ofBurkholderia pseudomallei as a Major Virulence Determinant.Infection and Immunity. 69:34-44. Reckseidler-Zenteno, S. L., Ling, J., Moore, R. A., and Woods, D. E. (2003). Recent Research Advances on the Pathogenesis of Melioidosis and Glanders. Recent Res. Dev. Infection and Immunity. 1:187-202. Reckseidler-Zenteno, S. L., DeVinney, R., and Woods, D. E. (2004). The Capsular Polysaccharide of Burkholderia pseudomalleiContributes to Survival in Serum by Reducing Complement Factor C3b Deposition. Infection and Immunity. 73:1106-1115. Moore, R. A., Reckseidler-Zenteno, S., Kim, H., Nierman, W., Yu, Y., Tuanyok, A., Warwara, J., DeShazer, D., and Woods, D. E. (2004). The Contribution of Gene Loss to the Pathogenic Evolution ofBurkholderia pseudomallei and Burkholderia mallei. Infection and Immunity. 72:4172-4187. Reckseidler-Zenteno, S. L., A. Tuanyok, R. Moore, and D. E. Woods. (2006). Genetic and Functional Characterization of the Capsules of Burkholderia pseudomallei. Infection and Immunity. Submitted. Reckseidler-Zenteno, S. L., R. Moore, and D. E. Woods. 2007. Genetics and Function of the Capsules of Burkholderia pseudomallei and Their Potential as Therapeutic Targets. Mini Rev. Med. Chem.9(2): 265-71. Reckseidler-Zenteno, S. L., D-F. Viteri, R. Moore, E. Wong, A. Tuanyok, and D. E. Woods. 2010. Characterization of the Type III Capsular Polysaccharide Produced by Burkholderia pseudomallei. J. Med. Microbiol. Accepted. Reckseidler-Zenteno, S.L. 2012. Capsular Polysaccharides Produced by the Bacterial Pathogen Burkholderia pseudomallei. In D. N. Karunaratn (ed.), The Complex World of Polysaccharides. In Tech Open Access Company. ISBN 978-953-51-0819-1, Published: October 31, 2012. de la Fuente-Núñez C, Reffuveille F, Mansour SC, Reckseidler-Zenteno SL, Hernández D, Brackman G, Coenye T, Hancock REW. 2015. D-enantiomeric peptides that eradicate wild-type and multi-drug resistant biofilms and protect against lethal Pseudomonas aeruginosa infections. Chemistry & Biology. 22:196–205. de la Fuente-Núñez C, Mansour SC, Wang Z, Jiang L, Breidenstein EBM, Elliott M, Reffuveille F, Speert DP, Reckseidler-Zenteno SL, Shen Y, Haapasalo M, Hancock REW. 2014. Anti-biofilm and immunomodulatory activities of peptides that inhibit biofilms formed by pathogens isolated from cystic fibrosis patients. Antibiotics. 3:509-526. Reckseidler, S. L., and Woods, D. E. Molecular Characterization of a Group 3 Capsule in Burkholderia pseudomallei. Abstr. UA/UC Conference On Infectious Diseases. May, 2000. Panorama, B.C. White, A. M., Reckseidler, S. L., and Woods, D. E. The Identification and Characterization of Extracellular Polysaccharide Synthesis and Transport Genes of Burkholderia stabilis. Abstr. UA/UC Conference On Infectious Diseases. May, 2000. Panorama, B.C. Reckseidler, S. L., and Woods, D. E. Identification of a Capsular Polysaccharide of Burkholderia pseudomallei as a Virulence Determinant. Abstr. Canadian Society of Microbiologists Annual General Meeting. June, 2002. Saskatoon, SK. Reckseidler, S.L., and Woods, D.E. Identification of a Capsular Polysaccharide of Burkholderia pseudomallei as a Virulence Determinant. Abstr. Canadian Bacterial Diseases Network Annual General Meeting. June, 2002. Saskatoon, SK. Reckseidler, S. L., and Woods, D. E. The Capsular Polysaccharide ofBurkholderia pseudomallei is Responsible for Persistence in the Serum through the Inhibition of Complement Factor C3b Binding and Phagocytosis. Abstr. Canadian Bacterial Diseases Network Annual General Meeting. June, 2002. Saskatoon, SK. Moore, R. A., Reckseidler-Zenteno, S, Nierman, W., Kim, H., Tuanyok, A., Warwara, J., DeShazer, D., and Woods, D. E. The Contribution of Gene Loss to the Pathogenic Evolution of Burkholderia pseudomallei and Burkholderia mallei. Abstr. American Society for Microbiology General Meeting. May, 2004. New Orleans, LA. Moir, D. T., Opperman, T., Reckseidler-Zenteno, S., Segal, J., Schweizer, H., and Woods, D. E. Target-specific Reporter Screens for B. pseudomallei Targets in a Surrogate Species. Abstr. Interscience Conference on Antimicrobial Agents and Chemotherapy October, 2004, Washington, DC. Reckseidler-Zenteno, S. L., Tuanyok, A., and Woods, D. E. Genetic and Functional Characterization of the Capsular Polysaccharides ofBurkholderia pseudomallei. Abstr. 4th World Melioidosis Congress. September, 2004, Singapore. Reckseidler-Zenteno, S.L., A. Tuanyok, R. Moore, E. Wong, and D. E. Woods. 2006. Genetic and Functional Characterization of the Capsules of Burkholderia pseudomallei. Abst. Conference on Infectious Diseases. May, 2006, Banff, AB. Reckseidler-Zenteno, S. L., R. A. Moore, D. Viteri, E. Wong, A. Tuanyok, and D. E. Woods. 2007. Genetic and Functional Characterization of a Capsule Produced by Burkholderia pseudomallei. Abst. 5th World Melioidosis Congress. November, 2007, Thailand.