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The physiology of cold: 1) Ecology, physiology and biochemistry of mammalian hibernation, 2) Physiology of hypothermia, including the establishment of animal models for prolonged survival under profoundly depressed body temperature, and 3) Mechanisms of improved cold tolerance in animals and men, including the modulation of maximum heat production in cold by nutritional and pharmacological manipulations and the strategies for prevention of accidental hypothermia in man.

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