Siraki, Arno - University of Alberta - Department of Pharmaceutical Sciences

个人简介

Dr. Arno G. Siraki received his Hon.B.Sc with a specialization in toxicology in 1998 from the University of Toronto. Arno continued his graduate studies in the Department of Pharmacology (under the supervision of Dr. Peter J. O’Brien). His MSc thesis was entitled “Antioxidant and Pro-Oxidant Nature of Catecholamines“ and was conferred the degree of MSc in 2000 while working at the same time in a QC lab at GSK (then GlaxoWellcome). He selected a research path and continued graduate studies in Dr. O’Brien’s laboratory as a PhD student. He was awarded an NSERC graduate fellowship for his thesis work (“Development of quantitative structure-activity relationships for metabolic activation of drugs and xenobiotics to reactive metabolites”) and was conferred his PhD in 2004 from the Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto. Arno’s post-doctoral studies were carried out at the National Institute of Environmental Health Sciences (NIH), located in Research Triangle Park, NC, USA from 2004 to 2008. Under the guidance of Dr. Ronald P. Mason, Head of the Free Radical Metabolite Group, Arno developed methods to detect protein free radicals through xenobiotic metabolism. Arno was recruited to the Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta in 2008 and is currently Associate Professor. His interests involve the association of free radicals with adverse drug reactions, identification of novel electron transfer intermediates (antioxidants), and the biological role of xenobiotic-induced protein free radicals.

研究领域

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Free radical metabolism of drugs and xenobiotics Proteomic changes from free radical metabolite exposure Electron transfer intermediates and novel antioxidant modulation of free radical metabolism Protein radical formation and consequences Neutrophil and HL-60 catalyzed free radical metabolism Relationship between protein modification and apoptosis Myeloperoxidase and other peroxidase enzymes involved in drugs and xenobiotic metabolism