Madden, Dean - Dartmouth College - Department of Chemistry

个人简介

A.B. Harvard University Ph.D. Harvard University

研究领域

The goal of our research is to understand the functional characteristics of ion channels and transporters in terms of their molecular structure. Transmembrane electrochemical gradients underpin a wide variety of essential physiological processes, including photosynthesis and respiration, muscle contraction and nerve signalling. Highly specialized ion transporters are responsible for establishing and maintaining these gradients, while ion channels are designed to exploit the gradients by selectively and/or temporarily permeabilizing the membrane in response to external stimuli.

近期论文

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A.N. Kettenbach, T. Wang, B.K. Faherty, D.R. Madden, S. Knapp, C. Bailey-Kellogg, S.A. Gerber (2012) Rapid determination of multiple linear kinase substrate motifs by mass spectrometry. Chem Biol. 19, 608-618. K.E. Roberts, P.R. Cushing, P. Boisguerin, D.R. Madden, B.R. Donald (2012) Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity. PLoS Comput Biol. 8, e1002477. K.M. Cihil,P. Ellinger, A. Fellows, D.B. Stolz, D.R. Madden, A. Swiatecka-Urban (2012) Disabled-2 Protein Facilitates Assembly Polypeptide-2-independent Recruitment of Cystic Fibrosis Transmembrane Conductance Regulator to Endocytic Vesicles in Polarized Human Airway Epithelial Cells. J Biol Chem. 287, 15087-15099. C.R. Midgett, A. Gill, D.R. Madden (2012) Domain architecture of a calcium-permeable AMPA receptor in a ligand-free conformation. Front Mol Neurosci. 4, 56. C.D. Bahl, D.R. Madden (2012) Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair. Protein Pept Lett. 19, 186-193. W. Park, C.R. Midgett, D.R. Madden, G.S. Chirikjian (2011) A Stochastic Kinematic Model of Class Averaging in Single-Particle Electron Microscopy. Int J Rob Res. 30, 730-754. J.F. Amacher, P.R. Cushing, J.A. Weiner, D.R. Madden (2011) Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitor. Acta Crystallogr. F67, 600-603. A. Gill, T.C. Scanlon, D.C. Osipovitch, D.R. Madden, K.E. Griswold (2011) Crystal structure of a charge engineered human lysozyme having enhanced bactericidal activity. PLoS One. 6, e16788. M.V. Navarro, P.D. Newell, P.V. Krasteva, D. Chatterjee, D.R. Madden, G.A. O'Toole, H. Sondermann (2011) Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biol. 9, e1000588. P.R. Cushing, L. Vouilleme, M. Pellegrini, P. Boisguerin, D.R. Madden (2010) A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR. Angew Chem Int Ed Engl. 49, 9907-9911. L. Vouilleme, P.R. Cushing, R. Volkmer, D.R. Madden, P. Boisguerin (2010) Engineering Peptide inhibitors to overcome PDZ binding promiscuity. Angew Chem Int Ed Engl. 49, 9912-9916. W. Park, D.R. Madden, D.N. Rockmore, G.S. Chirikjian (2010) Deblurring of Class-Averaged Images in Single-Particle Electron Microscopy. Inverse Probl. 26, 3500521-35005229. C.D. Bahl, C. Morisseau, J.M. Bomberger, B.A. Stanton, B.D. Hammock, G.A. O'Toole, D.R. Madden (2010) Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 192, 1785-1795. A. Birdsey-Benson, A. Gill, L.P. Henderson, D.R. Madden (2010) Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J Neurosci. 30, 1463-1470. C.D. Bahl, D.P. MacEachran, G.A. O'Toole, D.R. Madden. (2010) Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. Acta Crystallogr F66, 26-28. N. Nayeem, Y. Zhang, D.K. Schweppe, D.R. Madden, T. Green (2009) A nondesensitizing kainate receptor point mutant. Mol Pharmacol. 76, 534-542. A. Gill, A. Birdsey-Benson, B.L. Jones, L.P. Henderson, D.R. Madden (2008) Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists. Biochemistry, 47, 13831-13841. A. Gill, D.R. Madden (2008) Purification and crystallization of a non-GluR2 AMPA-receptor ligand-binding domain: a case of cryo-incompatibility addressed by room-temperature data collection. Acta Crystallogr, F64, 831-835. P.R. Cushing, A. Fellows, D. Villone, P. Boisguérin, D.R. Madden (2008) The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling. Biochemistry 47, 10084-10098. C.R. Midgett, D.R. Madden (2008) The quaternary structure of a calcium-permeable AMPA receptor: conservation of shape and symmetry across functionally distinct subunit assemblies. J Mol Biol. 382, 578-584. C.R. Midgett, D.R. Madden (2007) Breaking the bottleneck: eukaryotic membrane protein expression for high-resolution structural studies. J Struct. Biol., 160, 265-274.