El-Kadi, Ayman - University of Alberta - Department of Pharmaceutical Sciences

个人简介

Dr. El-Kadi is a professor in the Faculty of Pharmacy and Pharmaceutical Sciences at the University of Alberta (Edmonton, Alberta, Canada) since 2001. At University of Alberta he moved through the ranks from Assistant to Full Professor. He was the Chair of Pharmaceutical Sciences Division (2005-2008), Director of Graduate Studies (2008-2009), and the Associate Dean for Research and Graduate Studies (2009-2013). Dr. El-Kadi received his BSc in Pharmacy and MSc in Pharmacology from Tripoli and Benghazi University (Libya) in 1990 and 1994, respectively. In 1999 he received his PhD in Pharmacology from University of Montreal (Montreal, Quebec, Canada). Thereafter, he did postdoctoral training in Molecular Toxicology at the University of Western Ontario (London, Ontario, Canada). Dr. El-Kadi’s research interests are in the areas of Pharmacology and Molecular and Environmental Toxicology. His research resulted in over 130 peer-reviewed papers in prestigious journals and similar number of abstracts and presentations. His research is supported by the Natural Sciences and Engineering Research Council (NSERC), Canadian Institute of Health Research (CIHR), Heart and Stroke Foundation of Canada, Canadian Foundation for Innovation (CFI) and several Biotech companies. He has supervised significant number of undergraduate, MSc, PhD students and postdoctoral fellows. He has served as editor, associate editor and member of the editorial board for a number of journals in the pharmaceutical sciences.

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Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison MS, Chris Le X, Klotz LO, El-Kadi AO. Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med, 67:171-87, 2014. Amara IE, Anwar-Mohamed A, Abdelhamid G, El-Kadi AO.Mercury modulates the cytochrome P450 1a1, 1a2 and 1b1 in C57BL/6J mice: in vivo and in vitro studies.Toxicol Appl Pharmacol, 266(3):419-29, 2013. El-Sherbeni AA, El-Kadi AO. Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy. Biochem Pharmacol, 87(3):456-66, 2014. Althurwi HN, Tse MM, Abdelhamid G, Zordoky BN, Hammock BD, El-Kadi AO. Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy. Br J Pharmacol, 168(8):1794-807, 2013. El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO. Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. Toxicol Lett, 208(1):51-61, 2012. El Gendy MA, Somayaji V, El-Kadi AO. Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects. Planta Med, 76(7):671-7, 2010.