个人简介

M.S. Higher Chemical College of the Russian Academy of Sciences Ph.D. Iowa State University

研究领域

bioinorganic chemistry /redox reactivity /conformational dynamics of heme proteins

Molecular switching mediated by metal ions is an important process in the folding and function of metalloproteins, biological cell signaling, electron transfer and catalysis. When transition metal ions are involved, protein conformational switching affects the metal site's redox activity and conversely redox reactions themselves can act as triggers of protein rearrangements, enabling redox sensing. Despite the prominent role of redox-linked conformational changes in biology, the mechanisms of these transformations are poorly understood. Elucidating the principles that govern these phenomena could provide valuable insights for the design of novel conformational drugs targeting protein redox activity as well as switchable components for molecular electronics and artificial photosynthesis.

近期论文

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J. Muenzner, J. R. Toffey, E. J. Snider, Y. Hong, E. V. Pletneva "Becoming a peroxidase: cardiolipin-induced unfolding of cytochrome c", J. Phys. Chem. B 2013, ASAP. E. J. Snider, J. Muenzner, J. R. Toffey, Y. Hong, E. V. Pletneva "Multifaceted effects of ATP on cardiolipin-bound cytochrome c", Biochemistry 2013, 52, 993–995. A. J. Vincelli, D. S. Pottinger, F. Zhong, J. Hanske, S. G. Rolland, B. Conradt, E. V. Pletneva "Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins", Biochemistry 2013, 52, 653–666. Y. Hong, J. Muenzner, S. K. Grimm, E. V. Pletneva "Origin of the conformational heterogeneity of cardiolipin-bound cytochrome c", J. Am. Chem. Soc. 2012, 134, 18713–18723. T. L. Freeman, Y. Hong, K. H. Schiavoni, D. M. I. Bandara, E. V. Pletneva "Changes in the heme ligation during folding of a Geobacter sulfurreducens sensor GSU0935", Dalton. Trans. 2012, 41, 8022-8030. J. Hanske, J. R. Toffey, A. M. Morenz, A. J. Bonilla, K. H. Schiavoni, E. V. Pletneva "Conformational properties of cardiolipin-bound cytochrome c", Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 125-130. G. J. Pound, A. A. Pletnev, X. Fang, E. V. Pletneva "A small fluorophore reporter of protein conformation and redox state", Chem. Commun. 2011, 47, 5714-5716. J. L. Taylor, T. G. Moga, O. Karagiaridi, D. E. Wilcox, and E. V. Pletneva "Effects of DNA binding on the structural and redox properties of the [2Fe-2S] transcription factor SoxR", Chemtracts – Inorganic Chemistry, 2008, 21, 336-345.