个人简介

B.S., Yale University, 1990; Ph.D., University of California, 1996. Assistant Professor, Caltech, 2000-06; Associate Professor, 2006-10; Professor, 2010-17. Investigator, 2005-14, Arthur and Marian Hanisch Memorial Professor of Chemistry, 2017-present.

研究领域

Research in the Hsieh-Wilson group combines organic chemistry and neurobiology to understand the molecular basis of fundamental brain processes. We apply the tools of organic synthesis, biochemistry, molecular and cellular biology, biophysics and neurobiology to manipulate and understand small molecules, proteins and molecular interactions critical for neuronal communication, development, learning and memory.

Biochemistry and Molecular Biophysics; Chemistry

近期论文

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Pulsipher A.; Griffin M. E.; Stone S. E.; Hsieh-Wilson L. C.; "Long-lived engineering of glycans to direct stem cell fate." Angew Chem Int Ed Engl. 2015, 54, 1466-1470. Matho M. H.; de Val N.; Miller G. M.; Brown J.; Schlossman A.; Meng X.; Crotty S.; Peters B.; Xiang Y.; Hsieh-Wilson L. C.; Ward A. B.; Zajonc D. M.; "Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E," PLoS Pathog. 2014, 10, e1004495. Wibowo A.; Peters E. C.; Hsieh-Wilson L. C.; "Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins," J. Am. Chem. Soc. 2014, 136, 9528-9531. Pulsipher, A.; Griffin, M. E.; Stone, S. E.; Brown, J. M.; Hsieh-Wilson, L. C. "Directing Neuronal Signaling through Cell-Surface Glycan Engineering," J. Am. Chem. Soc. 2014, 136, 6794-6797. Hsieh-Wilson, L. C.; Griffin, M. E. "Improving Biologic Drugs via Total Chemical Synthesis," Science 2013, 342, 1332-1333. Clark, P. M.; Rexach, J. E.; Hsieh-Wilson, L. C. "Visualization of O-GlcNAc Glycosylation Stoichiometry and Dynamics using Resolvable Poly(ethylene glycol) Mass Tags," Curr. Protocols Chem. Biol. 2013, 5, 281-302. Griffin, M. E.; Hsieh-Wilson, L. C. "Synthetic Probes of Glycosaminoglycan Function," Curr. Op. Chem. Biol. 2013, 17, 1014-1022. Oh, Y. I.; Sheng, G.; Chang, S.-K.; Hsieh-Wilson, L. C. "Tailored Glycopolymers as Anticoagulant Heparin Mimetics," Angew. Chem. Int. Ed. 2013, 52, 11796-11799. Sheng, G.; Oh, Y. I.; Chang, S.-K.; Hsieh-Wilson, L. C. "Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity," J. Am. Chem. Soc. 2013, 135, 10898-10901. Dick, G.; Tan, C. l.; Alves, J. N.; Ehlert, E.; Miller, G.; Hsieh-Wilson, L. C.; Sugahara, K.; Oosterhof, A.; van Kuppevelt, T. H.; Verhaagen, J.; Fawcett, J. W.; Kwok, J. C. F. "Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E (CS-E) Motifs in Rodent Brains," J. Biol. Chem. 2013, 288, 27384-27395. Ramakrishnan, P.; Clark, P. M.; Mason, D. E.; Peters, E. C.; Hsieh-Wilson, L. C.; Baltimore, D. "Activation of the Transcriptional Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation," Science Signaling, 2013, 6 ra75. Yi, W; Clark, P. M.; Mason, D. E.; Keenan, M. C.; Hill. C.; Goddard, W. A., III; Peters, E. C.; Driggers, E. M.; Hsieh-Wilson, L. C. "Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism," Science 2012, 337, 975–980. Mattaini, K. R.; Vander Heiden, M. G. "Glycosylation to Adapt to Stress," Science 2012, 337, 925–926. Borman, S. "Glycosylation Linked to Cancer," Chem. Eng. News 2012, 90, 9. Goodman, C. "A GlcNAc Switch," Nat. Chem. Biol. 2012, 8, 809. Ray, L. B. "Metabolic Sensor," Sci. Signal. 2012, 5, ec225. Chaubard, J.-L.; Krishnamurthy, C.; Yi, W.; Smith, D.; Hsieh-Wilson, L. C. "Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-Galactose Glycan Biomarkers," J. Am. Chem. Soc. 2012, 134, 4489–4492. Brown, J. M.; Xia, J.; BinQuan, Z.; Cho, K.-S.; Rogers, C. J.; Gama, C. I.; Rawat, M.; Tully, S. E.; Uetani, N.; Mason, D.; Tremblay, M. L.; Peters, E. C.; Habuchi, O.; Chen, D. F.; Hsieh-Wilson, L. C. "A Sulfated Carbohydrate Epitope Inhibits Axon Regeneration After Injury," Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 4768–4773. Rexach, J. E.; Clark, P. M.; Mason, D. E.; Neve, R. L.; Peters, E. C.; Hsieh-Wilson, L. C. "Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation," Nature Chem. Biol. 2012, 8, 253–261. Rogers, C. J.; Hsieh-Wilson, L. C. "Microarray method for the rapid detection of glycosaminoglycan-protein interactions," Carbohydrate Microarrays: Methods and Protocols, Methods in Molecular Biology 2012, 808, 321–336.