个人简介

BS, SUNY at Oneonta, 1978 PhD, Case Western Reserve University, 1983 NIH Postdoctoral Fellow, Columbia University, 1983-86 Research Scientist, College of Physicians & Surgeons, Columbia University, 1986-89 Research Scientist, SUNBOR, Osaka, Japan, 1989-92 Ruth Salta Junior Investigator Achievement Award, 1993 Faculty Scholars Award, Alzheimers Association, 1994-97 John S. Diekoff Award, Distinguished Graduate Teaching, 2001

研究领域

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Biochemistry/Chemical Biology/Organic Chemistry/Beer Brewing/Bio-Organic Chemistry/Biophysical Chemistry/Drug Delivery/NMR/Structural Biology

The research in Professor Zagorski's group focuses on unraveling the molecular mechanisms associated with protein misfolding and amyloid formation. Numerous analytical techniques are utilized, including nuclear magnetic resonance (NMR), circular dichroism, atomic force microscopy, electron microscopy, analytical ultracentrifugation, peptide synthesis and peptide purification using high performance liquid chromatography. Frequent collaborations with scientists in the School of Medicine are fundamental to the long-term goals of the group's research, which is the eradication of human disease. Current research efforts focus on proteins with important pathological features in neurodegenerative diseases: the Ab peptide of Alzheimer's disease, the ABri peptide of Familial British dementia, a-synuclein of Parkinson's disease, the human prion and Doppel proteins of Mad Cow Disease, and the amyloid precursor protein of Alzheimer's disease.