个人简介

B.Sc., Albert-Ludwigs University of Freiburg, 1993; M.Sc.,1997; Ph.D., Rockefeller University, 2004. Caltech, 2010-.

研究领域

Structure-function studies of the nuclear pore complex and the histone-modifying machinery; X-ray crystallography Assistant: Margot Hoyt While working on the crystal structure of the 250-kDa Ca2+-calmodulin-dependent kinase II (CaMKII) core in John Kuryan’s laboratory, André developed a strong fascination for macromolecular assemblies. Inspired by the large CaMKII structure, André joined Günter Blobel’s laboratory with the idea of starting a comprehensive structural and functional characterization of the ~120 million Dalton nuclear pore complex (NPC), one of the largest proteinaceous assemblies in eukaryotic cells. In Günter Blobel’s laboratory André set up a structural biology subgroup that established the NPC as a viable target for an interdisciplinary divide-and-conquer approach, employing X-ray crystallographic, biochemical and in vivo studies, funded by a grant from the Leukemia and Lymphoma Society. Simultaneously, André stared a second line of research on the regulation of the histone-modifying machinery. André joined the Caltech faculty in November 2010. The Hoelz lab carries out structure-function studies of the nuclear pore complex with the ultimate goal of elucidating the atomic structure of the NPC. The applied structure determination as well as the described design principles of the NPC may serve as paradigms for other macromolecular assemblies.

Biochemistry and Molecular Biophysics

近期论文

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Stuwe, T.S., Correia, A.R., Lin, D.H., Paduch, M., Lu, V.T., Kossiakoff, A., Hoelz, A.* (2015). Science, Published online 12 February 2015. Davenport, A.M., Collins, L.N., Chiu, H., Minor, P.J., Sternberg, P.W., Hoelz, A.* (2014). Structural and Functional Characterization of the α-tubulin acetyltransferase MEC-17 J. Mol. Biol. 426, 2605-2616. Stuwe, T.S., Lin, D. H., Collins, L.M., Hurt, E., Hoelz, A.* (2014). Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins, Proc. Natl. Acad. Sci. USA 111, 2530-2535. Davenport, A.M., Huber, F.M., Hoelz, A.* (2014). Structural and Functional Analysis of Human SIRT1, J. Mol. Biol. 425, 507-509. Lin, D.H., Zimmermann, S., Stuwe, T.S., Stuwe, E., Hoelz, A.* (2013). Structural and Functional Analysis of the C-terminal Domain of Nup358/RanBP2, J. Mol. Biol. 425, 1318-1329. Kassube, S.A., Stuwe, T.S., Lin, D.H., Antonuk, C.D., Napetschnig, J., Blobel, G., Hoelz, A.* (2012). Crystal structure of the N-terminal domain of Nup358/RanBP2, J. Mol. Biol. 423, 752-765. Stuwe, T.S., Schada von Borzyskowski, L., Davenport, A.M., Hoelz, A. (2012). Molecular Basis for the Anchoring of Proto-Oncoprotein Nup98 to the Cytoplasmic Face of the Nuclear Pore Complex, J. Mol. Biol. 419, 330-346. Yoshida, K., Seo, H.S., Debler, E.W., Blobel, G., Hoelz, A. (2011). Structural and functional analysis of an essential heterotrimer on the cytoplasmic face of the nuclear pore complex, Proc. Natl. Acad. Sci. USA 108, 16571-16576. King, H.A., Hoelz, A., Crane, B.R., Young, M.W. (2011). Structure of an enclosed dimer formed by the drosophila period protein, J. Mol. Biol. 413, 561-572. Stuwe, T.S., Hoelz, A. (2011). Rae1: A new clue for nucleoporin leukemias, Cell Cycle 10, 2056. Hoelz, A.*,**, Debler, E.W., Blobel, G. (2011). Structure of the Nuclear Pore Complex, Annu. Rev. Biochem. 80, 613-643. Hsia, K.C., Hoelz, A. (2010). Crystal structure of α-COP in complex with ε-COP provides insight into the architecture of the COPI vesicular coat. Proc. Natl. Acad. Sci. USA 107, 11271-11276. Ren, Y., Seo, H.S., Blobel, G., Hoelz, A. (2010). Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc. Natl. Acad. Sci. USA 107, 10406-10411. Debler, E.W., Hsia, K.C., Nagy, V., Seo, H.S., Hoelz, A. (2010). Characterization of the membrane-coating Nup84 complex: Paradigm for the nuclear pore complex structure. Nucleus 1, 150-156. Nagy, V., Hsia, K.C., Debler, E.W., Kampmann, M., Davenport, A.M., Blobel, G., Hoelz, A. (2009). Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc. Natl. Acad. Sci. USA 106, 17693-17698. Seo, H.S., Ma, Y., Debler, E.W., Wacker, D., Kutik, S., Blobel, G., Hoelz, A. (2009). Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proc. Natl. Acad. Sci. USA 106, 14281-14286. Debler, E.W., Blobel, G., Hoelz, A. (2009). Nuclear transport comes full circle. Nat. Struct. Mol. Biol. 16, 457-459. Napetschnig, J., Kassube, S.A., Debler, E.W., Wong, R.W., Blobel, G. and Hoelz, A. (2009). Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proc. Natl. Acad. Sci. USA 106, 3089-3094. Debler, E.W., Ma, Y., Seo, H.S., Hsia, K.C., Noriega, T.R., Blobel, G., Hoelz, A. (2008). A fence-like coat for the nuclear pore membrane. Mol. Cell 32, 815-826. Stavropoulos, P., Nagy, V., Blobel G., Hoelz A. (2008). Molecular basis for the autoregulation of the protein acetyl transferase Rtt109. Proc. Natl. Acad. Sci. USA 105, 12236-12241.