Jickling, Glen - University of Alberta

个人简介

Glen Jickling has a strong interest in vascular neurology, including ischemic stroke and hemorrhagic stroke. Dr. Jickling’s research focuses on the role of the immune system in cerebrovascular disease including patterns of gene expression and epigenetic regulation. He has described RNA markers in blood as a method to distinguish stroke subtypes and predict cause in strokes of unclear etiology. Dr. Jickling is on the editorial boards of several journals. 1995 H. BSc, Biochemistry, University of Calgary, Calgary, Canada 2000-2003 MD, University of Alberta, Edmonton, Canada 2005-2008 Resident, Neurology, University of Alberta Hospital, Edmonton AB Canada 2009-2011 MSc, Clinical Research, University of California Davis, California USA

近期论文

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Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, Tian Y, Liu D, Davis RR, Lapchak PA, Sharp FR. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics 2010; 11:254. PMID: 20406488 Jickling GC, Xu H, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Turner RJ, Mesias M, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Signatures of cardioembolic and large-vessel ischemic stroke. Annals of Neurology 2010; 68(5):681-92. PMID: 21031583. Jickling GC, Sharp FR. Blood biomarkers of ischemic stroke. Neurotherapeutics 2011;8(3):349-60. PMID 21671123. Jickling GC, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Johnston SC, Verro P, Sharp FR. Profiles of lacunar and non-lacunar stroke. Annals of Neurology 2011; 70:477-485. PMID: 21796664. Jickling GC+, Zhan X+ (+Co-first authors), Tian Y, Stamova B, Xu H, Ander BP, Turner RJ, Mesias M, Verro P, Bushnell C, Johnston SC, Sharp FR. Transient ischemic attacks characterized by RNA profiles in blood. Neurology 2011; 77(19):1718-24. PMID: 21998319. Jickling GC, Zhan X, Stamova B, Ander BP, Liu D, Sison S, Verro P, Sharp FR. Prediction of cardioembolic, arterial and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke 2012; 43(8):2036-41. PMID: 22627989 Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison S, Verro P, Johnston SC, Sharp FR. Ischemic Transient Neurological Events Identified by Immune Response to Cerebral Ischemia. Stroke 2012; 43(4):1006-12. PMID: 22308247. Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Rothstein L, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Annals of Neurology 2013; 74(2):232-40. PMID: 23468366. Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab 2014; 34(2):185-99. PMID: 24281743. Jickling GC, Ander BP, Zhan X, Stamova B, Noblett D, Liu D. microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS One 2014; 9(6): e99283. PMID: 24911610. Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015; Jun;35 (6):888-901 PMID: 25806703. Jickling GC, Ander BP, Shroff N, Orantia M, Stamova B, Dykstra-Aiello C, Hull H, Zhan X, DaZhi Liu D, Sharp FR. Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology 2016; 87(21):2198-2205.