Jurasz, Paul K - University of Alberta - Department of Pharmacology

个人简介

BSc – Biological Sciences – 1998 PhD – Pharmacology - 2002

研究领域

Platelets are cell fragments physiologically known for maintaining hemostasis and pathologically for forming thrombi that occlude arteries and veins. These traditional roles of platelets have been known since the late 19th century. However, recent investigations from several laboratories around the world have demonstrated that platelets also play an important role regulating angiogenesis (new blood vessel growth). Platelets constitutively generate the potent angiogenesis inhibitor angiostatin as they circulate. In addition, they contain abundant pro- and anti-angiogenic mediators such as vascular endothelial growth and thrombospondin, which upon release from platelets granules help regulate new blood vessel growth. In my laboratory we study the pharmacological regulation of platelet-derived angiogenesis mediators in an attempt to inhibit growth of blood vessels to tumors and to promote therapeutic blood vessel growth for cardiovascular disease. Specifically, we are investigating the role of platelet-derived angiostatin plays in limiting angiogenesis, and how its production is regulated by serine and matrix metalloproteinases. Further, we are interested in how nitric oxide and protein kinase C signaling pathways influence the release of angiogenesis mediators from platelets. Finally, we are exploring how these platelet-derived angiogenesis mediators influence endothelial cell growth, migration, and ability to form capillaries.

近期论文

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Maayah ZH, Althurwi HN, Abdelhamid G, Lesyk G, Jurasz P and El-Kadi AO. (2016) CYP1B1 inhibition attenuates doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism. Pharmacol Res 105:28-43. PMID: 26772815 Yan M and Jurasz P. (2016) The role of platelets in the tumor microenvironment: From solid tumors to leukemia. Biochim Biophys Acta 1863(3):392-400. PMID: 26193075 Khan SR, Baghdasarian A, Nagar PH, Fahlman R, Jurasz P, Michail K, Aljuhani N and Siraki AG. (2015) Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals. Chem Biol Interact 239:129-38. PMID: 26102013 Lesyk G, Fong T, Ruvolo PP and Jurasz P. (2015) The potential of enzastaurin to enhance platelet aggregation and growth factor secretion: implications for cancer cell survival. J Thromb Haemost 13(8):1514-20. PMID: 25990653 Goldthorpe H, Jiang JY, Taha M, Deng Y, Sinclair T, Ge CX, Jurasz P, Turksen K, Mei SH and Stewart DJ. (2015) Occlusive lung arterial lesions in endothelial-targeted, fas-induced apoptosis transgenic mice. Am J Respir Cell Mol Biol 53(5):712-718. PMID: 25879383 Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. (2014) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicol Lett pii: S0378-4274(14)01372-1. PMID: 25300478 Yan M, Lesyk G, Radziwon-Balicka A and Jurasz P. (2014) Pharmacological regulation of platelet factors that influence tumor angiogenesis. Semin Oncol 41(3):370-7. PMID: 25023352 Mojiri A, Nakhaii-Nejad M, Phan WL, Kulak S, Radziwon-Balicka A, Jurasz P, Michelakis E, Jahroudi N. (2013) Hypoxia results in upregulation and de novo activation of von Willebrand factor expression in lung endothelial cells. Arterioscler Thromb Vasc Biol. 33(6):1329-38. PMID: 23580145 Radziwon-Balicka A, Moncada de la Rosa C, Zielnik B, Doroszko A, Jurasz P. (2013) Temporal and pharmacological characterization of angiostatin release and generation by human platelets: implications for endothelial cell migration. PLoS One. 8(3):e59281. PMID: 23555012 Moncada de la Rosa C, Radziwon-Balicka A, El-Sikhry H, Seubert J, Ruvolo PP, Radomski MW, Jurasz P. (2013) Pharmacologic protein kinase Cα inhibition uncouples human platelet-stimulated angiogenesis from collagen-induced aggregation. J Pharmacol Exp Ther. 345(1):15-24. PMID: 23386249 Radziwon-Balicka A, Ramer C, Moncada de la Rosa C, Zielnik-Drabik B, Jurasz P. (2013) Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: a hypoxia specific mechanism of action. Vascul Pharmacol. 58(4):280-91. PMID: 23220260 Radziwon-Balicka A, Moncada del la Rosa C, Jurasz P. (2012) Platelet-associated angiogenesis regulating factors: A pharmacological perspective. Can J Physiol Pharmacol. 90(6):679-88. PMID: 22512504 Jain S, Tran S, El Gendy MA, Kashfi K, Jurasz P, Velázquez-Martínez CA. (2012) Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs. J Med Chem. 55(2):688-96. PMID: 22148253 Jurasz P, Vurkova N, Kirshenbaum LA, Stewart DJ. (2011) VEGF Masks BNIP3-mediated Apoptosis of Hypoxic Endothelial Cells. Angiogenesis 14(2):199-207. PMID: 21318419 Jurasz P, Courtman D, Babaie S, Stewart DJ. (2010) Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials. Pharmacol Ther. 126(1):1-8. PMID: 20117135 Jurasz P, Ng D, Granton JT, Courtman D, Stewart DJ. (2010) Elevated platelet angiostatin and circulating endothelial microparticles in idiopathic pulmonary hypertension. Thromb. Res. 125, 53-60. PMID: 19427678