Burshtyn, Debby - University of Alberta - Department of Medical Microbiology & Immunology

研究领域

My research program encompasses studies of the cell and molecular biology of several receptors that regulate Natural Killer (NK) cells and viral regulation of the ligands of these receptors.

近期论文

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Poxvirus Infection-Associated Downregulation of C-Type Lectin-Related-b Prevents NK Cell Inhibition by NK Receptor Protein-1B. Williams KJ, Wilson E, Davidson CL, Aguilar OA, Fu L, Carlyle JR, and DN Burshtyn. 2012 Journal of Immunology 188:4980-91 (CIHR 36344) Montgomery, B.C, Cortes, H.D., Burshtyn, D.N., and J.L. Stafford. Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms. 2012 Developmental & Comparative Immunology 37:151-163 (CIHR 36344) Li, N.L., Davidson, C.E., Humar, A. and D.N. Burshtyn. Modulation of the inhibitory receptor leukocyte Ig-like receptor 1 on human natural killer cells. Frontiers in NK Cell Biology, available on line Sept 06, 2011. (CIHR 36344) The first Ig-domain of KIR3DL1 contacts MHC-I at a secondary site. Fu, L., Hazes B. and D.N. Burshtyn, 2011 Journal of Immunology 187:1816-25 (CIHR 36344) Davidson, C., Li, N. and D.N. Burshtyn. LILRB1 polymorphism and surface phenotype of natural killer cells. 2010 Human Immunology 71:942. (CIHR 36344) Osman, MS, Burshtyn, DN, Kane, KP. Activating Ly-49 receptors regulate LFA-1-mediated adhesion by NK cells. J Immunol 2007 Feb 1;178(3):1261-7 Kirwan, SE, Burshtyn, DN. Regulation of natural killer cell activity. Curr Opin Immunol. 2007 Feb;19(1):46-54 Treanor, B, Lanigan, PM, Kumar, S, Dunsby, C, Munro, I, Auksorius, E, Culley, FJ, Purbhoo, MA, Phillips, D, Neil, MA, Burshtyn, DN, French, PM, Davis, DM. Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses. J Cell Biol. 2006 Jul 3;174(1):153-61 Kirwan, S, Merriam, D, Barsby, N, McKinnon, A, Burshtyn, DN. Vaccinia virus modulation of natural killer cell function by direct infection. Virology. 2006 Mar 30;347(1):75-87 Kirwan, SE, Burshtyn, DN. Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).J Immunol. 2005 Oct 15;175(8):5006-15 Standeven, LJ, Carlin, LM, Borszcz, P, Davis, DM, Burshtyn, DN. The actin cytoskeleton controls the efficiency of killer Ig-like receptor accumulation at inhibitoryNK cell immune synapses. J Immunol. 2004 Nov 1;173(9):5617-25