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Stochastic Gate Dynamics Regulate the Catalytic Activity of Ubiquitination Enzymes. Manoj K. Rout, Curtis D. Hodge, Craig J. Markin, Xin Xu, J.N. Mark Glover, Wei Xiao, and Leo Spyracopoulos. Journal of the American Chemical Society, 136 (2014) 17446-17458. DOI: 10.1021/ja505440b Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 ΔE81 Defect. Anamika, Craig J. Markin, Manoj K. Rout and Leo Spyracopoulos. The Journal of Biological Chemistry, 289 (2014) 12852-12862. Inreased Precision for Analysis of Protein-Ligand Dissociation Constants Determined from Chemical Shift Titrations. Craig J. Markin and Leo Spyracopoulos. Journal of Biomolecular NMR, 53 (2012) 125-138. Catalytic Proficiency of Ubiquitin Conjugation Enzymes: Balancing pKa Suppression, Entropy, and Electrostatics. Craig J. Markin, Linda F. Saltibus, Melissa J. Kean, Ryan T. McKay, Wei Xiao, and Leo Spyracopoulos. Journal of the American Chemical Society, 132 (2010) 17775-17786. Mechanism for recognition of polyubiquitin chains: Balancing affinity through interplay between multivalent binding and dynamics. Craig J. Markin, Wei Xiao, and Leo Spyracopoulos. Journal of the American Chemical Society, 132 (2010) 11247-11258.