Xu, Bing - Brandeis University - Department of Chemistry

个人简介

After receiving his BS and MS from Nanjing University, Bing Xu obtained his PhD in 1996 from the University of Pennsylvania under the supervision of Timothy Swager. Before starting his independent research at the Hong Kong University of Science and Technology on the Aug. 2000, he was an NIH postdoctoral fellow with George Whitesides at Harvard University. Notably, Xu lab has made pioneering contributions in several research areas, including the integration of enzyme transformation (ET) and self-assembly (SA) for developing molecular biomaterials, synthesized the first dimeric nanoparticle consisting of quantum dot and nanomagnet for exploring nanoscience inside cells, reported the first case of using dopamine to anchor molecules on iron oxide surface, coined the term of "metallogel" and demonstrated the first use of metallogels for catalysis. and demonstrated the first case of using enzymatic transformation and self-assembly to inhibit cancer cells selectively. Bing Xu was tenured as an associated professor in Jan 2006, became a full professor in July 2008 at HKUST, then moved to Brandeis Unversity in fall of 2008. Based on his works in HKUST and Brandeis, Bing Xu was identified by THomson Reuters as "Highly-Cited Researchers in Chemistry" for 2014, 2015, and 2016. His currently is a professor in the Department of Chemistry, Brandeis University. His research focuses on the applications of molecular engineering in chemistry, materials science, biology, and medicine.

研究领域

IN-SITU ANTICANCER NANOMEDICINES RESPONSIVE BIOMATERIALS FOR CELL THERAPY ENZYMATIC NONCOVALENT SYNTHESIS MULTIFUNCTIONAL MAGNETIC NANOPARTICLES

近期论文

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Qiuxin Zhang, Weiyi Tan, Zhiyu Liu, Yichi Zhang Wei-Shao Wei, Seth Fraden, and Bing Xu* Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells Journal of the American Chemical Society, 2024. Jiaqi Guo, Annabelle Chang, and Bing Xu* "Auto-Cleaving Bond for Better Drugs" ChemMedChem, 2024. Meihui Yi, Gabriel Ashton-Rickardt, Weiyi Tan, Zhiyu Liu, Hongjian He, Jer-Tsong Hsieh, Bing Xu* "Accelerating Cellular Uptake with Unnatural Amino Acid for Inhibiting Immunosuppressive Cancer Cells" Chemistry A European. J., 2024. Yuchen Qiao, Grace Wu, Zhiyu Liu, Hongjian He, Weiyi Tan, Bing Xu* "Assessment of the Enzymatic Dephosphorylation Kinetics in the Assemblies of a Phosphopentapeptide that Forms Intranuclear Nanoribbons" Biomacromolecules, 2024, 25, 1310-1318. Zhiyu Liu, Jiaqi Guo, Yuchen Qiao, and Bing Xu* “Enzyme-Instructed Intracellular Peptide Assemblies" Accounts of Chemical Research, 2023, 56, 3076-3088. Jiaqi Guo, Weiyi Tan, Hongjian He, and Bing Xu* “Autohydrolysis of Diglycine Activated Succinic Esters Boosts Cellular Uptake” Angewante Chemie International Edition, 2023, 62, e202308022. Meihui Yi, Zhaoqianqi Feng, Hongjian He, Daniela M. Dinulescu, and Bing Xu* “Evaluating Alkaline Phosphatase-Instructed Self-Assembly of D-Peptides for Selectively Inhibiting Ovarian Cancer Cells” Journal of Medicinal Chem 2023, 66, 10027-10035 Yuchen Qiao, and Bing Xu* “Peptide Assemblies for Cancer Therapy” ChemMedChem 2023, 18, e20230258. Jiaqi Guo, Fengbin Wang*, Yimeng Huang, Hongjian He, Weiyi Tan, Meihui Yi, Edward H. Egelman*, and Bing Xu* “Cell Spheroid Creation by Transcytotic Intercellular Gelation” Nature Nanotechnology, 2023, in press. Jiaqi Guo, Shane T. Rich-New, Chen Liu, Yimeng Huang, Weiyi Tan, Hongjian He, Meihui Yi, Xixiang Zhang, Edward H. Egelman*, Fengbin Wang*, and Bing Xu* Hierarchical Assembly of Intrinsically Disordered Short Peptides” Chem 2023, in press. Adrianna N. Shy, Jiashu Xu, Beom Jin Kim, and Bing Xu* “An Exploration of Multiple Component Peptide Assemblies by Enzyme-Instructed Self-Assembly” ChemSystemChem, 2023, 1, e202200041 Shuang Liu, Qiuxin Zhang, Hongjian He, Meihui Yi, Weiyi Tan, Jiaqi Guo, and Bing Xu* “Intranuclear Nanoribbons for Selective Killing of Osteosarcoma Cells” Angewandte Chemie International Edition, 2022, 61, in press. Meihui Yi, Fengbin Wang, Weiyi Tan, Jer-Tsong Hsieh*, Edward H. Egelman*, and Bing Xu* “Enzyme Responsive Rigid-Rod Aromatics Target “Undruggable” Phosphatases to Kill Cancer Cells in Mimetic Bone Microenvironment” Journal of the American Chemical Society 2022, 144, 13055-13059. Weiyi Tan, Qiuxin Zhang, Monica C Quiñones-Frías, Alan Hsu, Yichi Zhang, Avital Rodal, Pengyu Hong, Hongbo Luo, Bing Xu* “Enzyme Responsive Peptide Thioesters for Targeting Golgi Apparatus “, Journal of the American Chemical Society 2022, 144, 6709-6713. Qiuxin Zhang, Weiyi Tan, and Bing Xu* “Enzymatic Noncovalent Synthesis for Targeting Subcellular Organelles” ChemPlusChem, 2022, 87, e202200060. Weiyi Tan, Qiuxin Zhang, Pengyu Hong*, Bing Xu* “A Self-Assembling Probe for Imaging the States of Golgi Apparatus in Live Single Cells”, Bioconjugate Chemistry, 2022, in press. Qiuxin Zhang, Weiyi Tan, Bing Xu* “Synthesis and Bioactivity of Pyrrole-Conjugated Phosphopeptides” Beilstein Journal of Organic Chemistry, 2022, 18, 159-166. Meihui Yi, Weiyi Tan, Jiaqi Guo, Bing Xu* “Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications” Chemical Communications, 2021, 57, 12870-12879. Shuang Liu, Qiuxin Zhang, Adrianna N. Shy, Meihui Yi, Hongjian He, Shijiang Lu, Bing Xu* “Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells (iPSCs)” Journal of the American Chemical Society 2021, 143, 15852-15862. Meihui Yi, Jiaqi Guo, Hongjian He, Weiyi Tan, Nya Harmon, Kesete Ghebreyessus, Bing Xu* “Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides” Soft Matter 2021, 17, 8590 - 8594. Hongjian He; Jiaqi Guo; Bing Xu* “Enzymatic Delivery of Magnetic Nanoparticles into Mitochondria of Live Cells” ChemNanoMat, 2021, 7, 1104-1107. Weiyi Tan, Qiuxin Zhang, Jiaqing Wang, Meihui Yi, Hongjian He, and Bing Xu* “Enzymatic Assemblies of Thiophosphopeptides Instantly Target Golgi Apparatus and Selectively Kill Cancer Cells” Angewandte Chemie International Edition, 2021, 60, 12796-12801. Hongjian He; Jiaqi Guo; Jiashu Xu; JIaqing Wang; Shuang Liu; Bing Xu* “The Dynamic Continuum of Nanoscale Peptide Assemblies Facilitates Endocytosis and Endosomal Escape” Nano Letters, 2021, 9, 4878-4085. Dongsik Yang, Hongjian He, Beom Jin Kim, Bing Xu* “Peptide Assemblies Mimicking Chaperones for Protein Trafficking” Bioconjugate Chemistry, 2021, 32, 502-506. Jingyu Wang,* Hui Li, and Bing Xu* “Biological functions of supramolecular assemblies of small molecules in cellular environment” RSC Chemical Biology, 2021, 2, 289-305. drianna N. Shy, Huaimin Wang, Zhaoqianqi Feng and Bing Xu* “Heterotypic Supramolecular Hydrogels Formed by Noncovalent Interactions in Inflammasomes” Molecules, 2021, 26, 77. Dongsik Yang, Beom Jin Kim, Hongjian He, and Bing Xu* "Enzymatically Forming Cell Compatible Supramolecular Assemblies of Tryptophan-Rich Short Peptides" Peptide Science. 2021, 113, e24173. Hongjian He, Weiyi Tan, Jiaqi Guo, Meihui Yi, Adrianna N. Shy and Bing Xu* “Enzymatic Noncovalent Synthesis” Chemical Reviews, 2020, 18, 9994-10078. Hongjian He, Xinyi Lin, Difei Wu, Jiaqing Wang, Jiaqi Guo, Douglas R. Green, Hongwei Zhang, and Bing Xu* “Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells” Cell Reports Physical Science, 2020, 1, 100270. Hongjian He, Shuang Liu, Difei Wu, and Bing Xu* "Enzymatically-Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors for Selectively Killing Cancer Cells" Angewandte Chemie International Edition 2020, 59, 16445-16450. Dongsik Yang, Hongjian He and Bing Xu* “Enzyme-Instructed Morphological Transition of the Supramolecular Assemblies of Branched Peptides” Beilstein Journal of Organic Chemistry, 2020, 16, 2700-2718.