Snider, Barry - Brandeis University - Department of Chemistry

个人简介

Education: B. Sc. Chem. University of Michigan, Ann Arbor, MI 1970 Ph. D. Harvard University, Cambridge, MA 1973 (Advisor, E. J. Corey) Postdoctoral Columbia University, New York, NY 1973-1975 (Advisor, Ronald Breslow) Employment Assistant Professor, Princeton University, 1975-1981 Associate Professor, Brandeis University, 1981-1985 Professor, Brandeis University, 1985- Breskin Professor of Organic Chemistry, Brandeis University, 1998- Chair, Chemistry Department, Brandeis University, 1992-1995, 2013-present Awards and Honors National Science Foundation Predoctoral Fellowship 1970-1973 National Institutes of Health Postdoctoral Fellowship, 1975 DuPont Young Faculty Grant, 1978, 1979 UpJohn Young Faculty Grant, 1977, 1978 Fellow of the Alfred P. Sloan Foundation 1979-1983 Dreyfus Foundation Teacher-Scholar Award, 1982-1987 Visiting Research Scholar, Tokyo Institute of Technology, 1992 Member, NIH Medicinal Chemistry Study Section, 1992-1997 Chair, NIH Medicinal Chemistry Study Section, 1995-1997 Cope Scholar Award (American Chemical Society), 1995 Japan Society for Promotion of Science Fellowship, 1999 Honorary Professor East China University of Science and Technology 2006 Chair-Elect, Chair, Past Chair, Organic Chemistry Division of the ACS, 2006-2008 Fellow, American Chemical Society, 2011 Secretary/Treasurer, Organic Chemistry Division of the ACS, (Elect 2013) 2014-2017

研究领域

Development of new synthetic methods. Mechanisms of synthetically important reactions. Total synthesis of natural products. I work on the development of new methods for the construction of highly functionalized organic molecules and the synthesis of natural products, which often have useful drug-like activity but are often not available in sufficient quantity from the plants and animals that produce them. A large number of the drugs currently in use, including the statins, most antibiotics and many cancer drugs are either natural products or derived from them. Thus this chemistry is closely related to work that is done in the pharmaceutical industry.

近期论文

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Zhou, Q.; Snider, B. B. "Synthesis of Phantasmidine" Org. Lett. 2011, 13, 526–529. Yu, M.; Snider B. B. “Syntheses of Chloroisosulochrin and Isosulochrin and Biomimetic Elaboration to Maldoxin, Maldoxone, Dihydromaldoxin, and Dechlorodihydromaldoxin” Org. Lett. 2011, 13, 4224-4227. Lin, H.-Y.; Causey, R.; Garcia, G. E.; Snider, B. B. “Synthesis of (±)-7-Hydroxylycopodine” J. Org. Chem. 2012, 76, 7136-7149. Layre, E.; Lee, H. J.; Young, D. C.; Jezek Martinot A.; Buter, J.;Minnaard, a. J.; Annand, J. W.; Fortune, S. M.; Snider, B. B.; Matsunaga, I.; Rubin, E. J.; Alber, B.; Moody, D. B.; “Molecular Profiling of M. tuberculosis Identifies Tuberculosinyl Nucleoside Products of the Virulence-Associated Enzyme Rv3378c” Proc. Nat. Acad. Sci. 2014, 2978-2983. Xie, C.; Runnegar, M. T. C.; Snider, B. B. “Total Synthesis of (±)-Cylindrospermopsin” J. Am. Chem. Soc. 2000, 122, 5017-5024. http://dx.doi.org/10.1021/ja000647j Snider, B. B.; Lin, H. “Total Synthesis of (-)-FR901483” J. Am. Chem. Soc. 1999, 121, 7778-7786. http://dx.doi.org/10.1021/ja991160h Snider, B. B.; Lin, H. “Biomimetic Total Syntheses of (-)-TAN1251A, (+)-TAN1251B, (+)-TAN1251C, and (+)-TAN1251D” Organic Letters, 2000, 2, 643-646. http://dx.doi.org/10.1021/ol991401q Snider, B. B.; Hawryluk, N. A. “Synthesis of (-)-Dysiherbaine” Organic Letters, 2000, 2, 635-638. http://dx.doi.org/10.1021/ol991393d He, F.; Foxman, B. M.; Snider, B. B. “Total Syntheses of (-)-Asperlicin and (-)-Asperlicin C” J. Am. Chem. Soc. 1998, 120, 6417-6418. http://dx.doi.org/10.1021/ja9809408 Snider, B. B.; Shi, Z. “Biomimetic Synthesis of the Pentacyclic Nucleus of Ptilomycalin A” J. Am. Chem. Soc. 1994, 116, 549-557. http://dx.doi.org/10.1021/ja00081a015 Snider, B. B.; Chen, J. “Synthesis of Batzelladine E and its E Isomer” Tetrahedron Lett. 1998, 39, 5697-5700. http://dx.doi.org/10.1016/S0040-4039(98)01196-4 Snider, B. B.; Song, F.; Foxman, B. M. “Total Syntheses of (±)-Anchinopeptolide D and (±)-Cycloanchinopeptolide D” J. Org. Chem. 2000, 65, 793-800. http://dx.doi.org/10.1021/jo991454l Snider, B. B.; Vo, N. H.; O'Neil, S. V. “Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A” J. Org. Chem. 1998, 63, 4732-4740. http://dx.doi.org/10.1021/jo9804700 Snider, B. B.; Liu, T. “Synthesis of (±)-Cylindricines A, D, and E” J. Org. Chem. 1997, 62, 5630-5633. http://dx.doi.org/10.1021/jo970536b Snider, B. B.; Zeng, H. “Total Syntheses of (-)-Fumiquinazolines A, B, C, E, H, and I. Approaches to the Synthesis of Fiscalin A.” J. Org. Chem. 2003, 68, 545-563. http://dx.doi.org/10.1021/jo0264980 Shi, B.; Hawryluk, N. A.; Snider, B. B. “Formal Synthesis of (±)-Guanacastepene” J. Org. Chem. 2003, 68, 1030-1042. http://dx.doi.org/10.1021/jo026702j Snider, B. B.; Ahn, Y.; O’Hare, S. “Total Synthesis of (±)-Martinellic Acid” Org. Lett. 2001, 3, 4217-4220. http://dx.doi.org/10.1021/ol016884o Snider, B. B.; Gu, Y.-H. “Total Synthesis of (-)- and (+)-Dysibetaine” Org. Lett. 2001, 3, 1761-1763. http:/dx.doi.org/10.1021/ol015954o Snider, B. B.; Song, F. “Total Synthesis of (-)-Salicylihalamide A” Org. Lett. 2001, 3, 1817-1820. http://dx.doi.org/10.1021/ol015822v Snider, B. B.; Shi, B. “Synthesis of pyrinodemins A and B. Assignment of the double bond position of pyrinodemin A” Tetrahedron Lett. 2001, 40, 139-1642. http://dx.doi.org/10.1016/S0040-4039(01)00003-X Gao, X.; Snider, B. B. “Syntheses of (-)-TAN-2483A, (-)-Massarilactone B, and the Fusidilactone B Ring System. Revision of the Structures of and Syntheses of (±)-Waol A (FD-211) and (±)-Waol B (FD-212)” J. Org. Chem. 2004, 69, 5517-5527. http://dx.doi.org/10.1021/jo0358628 Neubert, B. J.; Snider, B. B. “Synthesis of (±)-Phloeodictine A1” Org. Lett. 2003, 5, 765-768. http://dx.doi.org/10.1021/ol034042e Gu, Y.; Snider, B. B. “Synthesis of ent-Haterumalide NA (ent-Oocydin A) Methyl Ester” Org. Lett. 2003, 5, 4385-4388. http://dx.doi.org/10.1021/ol0356789 Snider, B. B.; Che, Q. “Synthesis of Cladobotryal, CJ16,169 and CJ16,170” Org. Lett. 2004, 6, 2877-2880. 248. http://dx.doi.org/10.1021/ol049130t