研究领域

biomaterials; tissue engineering; drug delivery

Dr. Uludag's research focuses in two areas: regeneration of bone tissue using protein-based growth factors, and design of polymeric biomaterials for delivery of nucleic acid-based therapeutics. These two avenues of exploration overlap significantly in working philosophy, and the activity in each focus typically complements the other. He collaborates with partners in the Faculties of Medicine and Pharmacy, and other institutions around the world.

近期论文

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E.K. Tsekoura, Remant Bahadur KC, H. Uludağ. Biomaterials to facilitate delivery of RNA agents in bone regeneration and repair. ACS Biomaterials Science and Engineering (2017) in press. H. Kaur, H. Uludağ, D.N. Dederich, T. El-Bialy. Effect of increasing Low Intensity Pulsed Ultrasound and functional appliance on mandibular condyle in growing rats. J. Ultrasound in Medicine (2017) in press. H.M. Aliabadi, P. Mahdipoor, M. Bisoffia, J.C. Hugh, H. Uludağ. Single and combinational siRNA therapy of cancer cells: probing changes in targeted and non-targeted mediators after siRNA treatment. Molecular Pharmaceutics (2016) 13: 4116-4128. M.B. Parmar, B.E. Arteaga Ballesteros, T. Fu, Remant Bahadur KC, H.M. Aliabadi, J.C. Hugh, R. Löbenberg, H. Uludağ. Multiple siRNA delivery against cell cycle and anti-apoptosis proteins using lipid-substituted polyethylenimine in triple-negative breast cancer and non-malignant cells. J. Biomed. Mat. Res. A (2016) 104: 3031-3044. K. Utsuno, N. Jouna, E. Tanaka, Y. Kojima, H. Uludağ. Low molecular weight branched PEI binding to linear DNA. Chem. Pharmaceut. Bull (2016) 64: 1484–1491. S.M. Garg, A. Falamarzian, M.R. Vakili, H.M. Aliabadi, H. Uludağ, A. Lavasanifar. Polymeric micelles for MCL-1 gene silencing in breast tumors following systemic administration. Nanomedicine (2016) 11: 2319-2339. T.A. Aldosary, H. Uludağ, M. Doschak, T. El-Bialy. Osteogenic differentiation of human umbilical cord peri-vascular 1 cells using Low Intensity Pulsed Ultrasound. Journal of Stem Cell Research & Therapy (2016) 6: 335. H. Uludağ, B. Landry, J. Valencia-Serna, Remant-Bahadur K.C. and D. Meneksedağ-Erol. Current attempts to implement siRNA-Based RNAi in leukemia models. Drug Discovery Today (2016) 21: 1412-1420. P. Zhu, H.M. Aliabadi, H. Uludağ, J. Han. Identification of potential drug targets in breast cancer signaling pathway using stochastic logical models. Scientific Reports (2016) 6:23078. J. Valencia-Serna, P. Chevallier, G. Laroche, H. Uludağ. Fibronectin-modified surfaces for evaluating the influence of cell adhesion on sensitivity of leukemic cells to siRNA nanoparticles. Nanomedicines (2016) in press. B. Thapa, S. Plianwong, Remant Bahadur KC, B. Rutherford, H. Uludağ. Small hydrophobe substitution on polyethylenimine for plasmid DNA delivery: Optimal substitution is critical for effective delivery. Acta Biomaterialia (2016) 33: 213-224. B. Landry, H. Gül-Uludağ, S. Plianwong, C. Kucharski, Z. Zak, M.B. Parmar, O. Kutsch, H. Jiang, J. Brandwein, H. Uludağ. Targeting CXCR4/SDF-1 axis by lipopolymer complexes of siRNA in acute myeloid leukemia. J Control Release (2016) 224: 8-21. D. Meneksedag-Erol, Remant Bahadur KC, T. Tang, H. Uludağ. A delicate balance when substituting a small hydrophobe onto low molecular weight polyethylenimine to improve its nucleic acid delivery efficiency. ACS Applied Materials & Interfaces (2015) 7: 24822-24832. T.A. Aldosary, H. Uludağ, M. Doschak, T. El-Bialy. Effect of ultrasound on human umbilical cord peri-vascular cells. J. Biomedical Engineering & Informatics (2015) 1: 70-81. H.M. Aliabadi, P. Mahdipoor, C. Kucharski, N. Chan, H. Uludağ. Effect of siRNA pre-exposure on subsequent response to siRNA therapy. Pharm. Res. (2015) 32: 3813-3826. B. Landry, J. Valencia-Serna, H. Gul-Uludağ, X. Jiang, A. Janowska-Wieczorek, J. Brandwein, H. Uludağ. Progress in RNAi mediated molecular therapy of acute and chronic myeloid leukemia. Molecular Therapy Nucleic Acids (2015) 4: e240. Remant Bahadur KC, C. Kucharski, H. Uludağ. Additive nanocomplexes of cationic lipopolymers for improved non-viral gene delivery to mesenchymal stem cells. J. Mat. Chem. (2015) 3: 3972-3982. D. Meneksedağ-Erol, T. Tian, H. Uludağ. Probing the effect of miRNA on siRNA – PEI polyplexes. J. Phys. Chem. B (2015) 119: 5475-5486. M.B. Parmar, H.M. Aliabadi, P. Mahdipoor, C. Kucharski, R. Maranchuk, J.C. Hugh, H. Uludağ. Targeting cell cycle proteins in breast cancer cells with siRNA by using lipid-substituted polyethylenimines. Frontiers in Biotechnology & Bioengineering (2015) 3:14. M. Parmar, H. Uludag. Cell Cycle Regulation as a Target for RNAi Mediated Cancer Therapy. In Nanomedicines: Design, Delivery and Detection, M. Braddock (Ed.) (2015) in press. Remant K.C., H. Uludag. PEI and Its Derivatives in Gene Delivery. In Polymers and Nanomaterials in Gene Delivery. R. Narain (Ed). Woodhead Publishing Limited, Cambridge, UK (2015) in press. H.M. Aliabadi, H. Uludag. Nanoparticle Carriers to Overcome Biological Barriers Barriers to siRNA Delivery. In Nanomedicines: Design, Delivery and Detection, M. Braddock (Ed.) (2015) in press. A. Falamarzian, H.M. Aliabadi, 0. Molavi, J.M. Seubert, R. Lai, H. Uludag, A. Lavasanifar. Effective down-regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast tumor cells to conventional chemotherapy. J. Biomed. Mat. Res. A. (2014) 102: 3216-3228. L Rose, C. Kucharski, P. Mandipoor, H. Uludag. Pharmacokinetics and transgene expression by polytheylenimine-based pDNA complexes after in vivo gene delivery. Biomaterials Science (2014) 2: 833-842. H. Kaur, H. Uludag, T. El-Bialy. Effect of non-viral plasmid delivered basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on mandibular condylar growth: a preliminary study. BioMed Research Int. (2014) 2014:426710.