研究领域

Study of organic synthesis/including its interface with other areas of chemical science/including organometallics and chemical biology.

Our lab studies interesting problems in organic synthesis and chemical biology. Our chemical biology program is directed at the design and synthesis of carbohydrate clusters which mimic important binding surfaces in biology. One target is the portion of HIV protein gp120 which is bound by 2G12, a broadly-neutralizing antibody which protects against the virus. Good mimics of this glycocluster have potential as HIV vaccines. Rather than design and test individual glycoclusters, we are using a directed evolution-based approach, in which the best gp120 mimics are selected from a diverse glycocluster library by their ability to bind 2G12. This directed evolution is accomplished by attachment of sugars to a library of DNA sequences using click chemistry, a technique which we term SELMA (SELection with Modified Aptamers). We are also applying SELMA and related methods to other problems in molecular recognition.

近期论文

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Boron Carboxylate Catalysis of Homoallylboration. Dugas, G. J.; Lam, Y.-H.; Houk, K. N.; Krauss, I. J. J. Org. Chem. 2014 , ASAP "Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12". Horiya, S.; Bailey, J.; Temme, J.; Guillen Schlippe, Y.; Krauss, I. J. Am. Chem. Soc., Just accepted High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12Temme, S. J.; MacPherson, I. S.; DeCourcey, J. F.; Krauss, I. J. J. Am. Chem. Soc. 2014 , 136(5), 1726-1729. Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA. Temme, J. S.; Drzyzga, M.; MacPherson, I. S.; Krauss, I. J. Chem. - Eur. J. 2013 , 19(51), 17291-17295. Enantioselective Homocrotylboration of Aliphatic Aldehydes. Lin, H.; Pei, W.; Wang, H.; Houk, K. N.; Krauss, I. J. J. Am. Chem. Soc. 2013, 135(1), 82-85. Homoallylboration and Homocrotylboration of Aldehydes. Pei, W.; Krauss, I. J J. Am. Chem. Soc. 2011, 133(46), 18514-18517. Multivalent Glycocluster Design Through Directed Evolution. MacPherson, I. S.; Temme. J. S.; Habeshian, S.; Felczak, K.; Pankiewicz, K.; Hedstrom, L.; Krauss, I. J Angew. Chem. Int. Ed. 2011, 50(47), 11238-11242. A Short Asymmetric Route to the Bromophycolide A and D Skeleton. Lin, H.; Pochapsky, S.S.; Krauss, I. J Org. Lett. 2011, 13(5), 1222-1225. Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative. Gao, Y.; Kuang, Y.; Guo, Z-F.; Guo, Z.; Krauss, I. J.; Xu, Bing J. Am. Chem. Soc. 2009, 131(38), 13576-13577. Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims. Nagorny, P.; Krauss, I. J. Njardarson, J. T.; Perez, L.; Gaul, C.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J. Tetrahedron Lett. 2010, 51(30), 3873-3875. Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog. Oskarsson, T.; Nagorny, P.; Krauss, I. J.; Perez, L.; Mandal, M.; Yang, G.; Ouerfelli, O.; Xiao, D.; Moore, M. S.; Massague, J.; Danishefskhy, S. J. J. Am. Chem. Soc. 2010, 132(9), 3224-3228. A New Model for the Presentation of Tumor-Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via Ring-Closing Metathesis. Jeon, I.; Lee, D.; Krauss, I. J.; Danishefsky, S. J. J. Am. Chem. Soc. 2009, 131(40), 14337-14344. An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions. Joyce, J. G.; Krauss, I. J.; Song, H. C.; Opalka, D. W.; Grimm, K. M.; Nahas, D. D.; Esser, M. T.; Hrin, R.; Feng, M.; Dudkin, V. Y.; Chastain, M.; Shiver, J. W.; Danishefsky, S. J. Proc. Natl. Acad. Sci. USA 2008, 105(41), 15684-15689. Total Synthesis of Spirotenuipesines A and B. Dai, M.; Krauss, I. J.; Danishefsky, S. J. J. Org. Chem. 2008, 73(24), 9576-9583. Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody. Krauss, I. J.; Joyce, J. G.; Finnefrock, A. C.; Song, H. C.; Dudkin, V. Y.; Geng, X.; Warren, J. D.; Chastain, M.; Shiver, J. W.; Danishefsky, S. J. J. Am. Chem. Soc. 2007, 129(36), 11042-11044. Total synthesis of (+)-isomigrastatin. Krauss, I. J.; Mandal, M.; Danishefsky, S. J. Angew. Chem. Int. Ed. 2007, 46(29), 5576-5579. Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature. Krauss, I. J.; Leighton, J. L. Org. Lett. 2003, 5(18), 3201-3203. Highly Regioselective and Diastereoselective Directed Hydroformylation of Allylic Ethers: A New Approach to Propionate Aldol Synthesis. Krauss, I. J; Wang, C. C-Y.; Leighton, J. L. J. Am. Chem. Soc. 2000, 123(46), 11514-11515.