个人简介

Dr. Hyo-Jick Choi is an assistant professor in the Department of Chemical & Materials Engineering at the University of Alberta, and runs a sustainable engineering and drug delivery design (SEƎD) lab investigating new materials directed towards health and environmental applications. He has amassed knowledge in different disciplines of science as the result of his diverse background. He received his B.S. and M.S. degrees in Ceramic Engineering from Yonsei University in Korea in 1999 and 2001, respectively. He continued his Ph.D. studies in Biomedical Engineering at UCLA (2002-2006) and at the University of Cincinnati (2006-2007). His research resulted in generation of two start-up companies. After completing his Ph.D. studies, he worked in the capacity of R&D manager in the company and played critical role in the commercialization of these technologies. He then conducted postdoctoral research in the School of Chemical and Biomolecular Engineering at Georgia Institute of Technology (2009-2010). Prior to joining the University of Alberta, Dr. Choi served as research assistant professor in Environmental Engineering Department at the University of Cincinnati, where he worked as the Principal Investigator of oral vaccine delivery project.

研究领域

Artificial organelle; Living-nonliving hybrid systems; Drug delivery systems; Oral vaccine delivery; Transdermal vaccine delivery using microneedles; Pandemic disease control measures

Dr. Hyo-Jick Choi is a firm believer of the decisive role of innovative technologies in improving the quality of life. With this belief, he has dedicated his research career to engineer sustainable technologies, which are focused on resolving global issues in environment and health. His past research areas include development of new nanobiological systems and their applications in fabrication of engineering devices with life-like functionality, artificial cells, water purification membrane, carbon sequestration/biofuel production, and transdermal influenza vaccine delivery using microneedles. His current and future research interests are: 1. advanced living/nonliving hybrid systems for energy production and environmental control measures, and 2. nanotechnology to combat epidemic/pandemic disease development of new vaccination technology (transdermal/oral vaccine delivery design) development of airborne pathogen deactivation methods. The overall goal of his research is to develop nano-scale systems with precisely tailored materials by using interdisciplinary approach and focus on their commercial applications in energy, environment, and global health problems.

近期论文

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F.-S. Quan, I. Rubino, S.H. Lee, B. Koch, H. –J. Choi*, Scientific Reports, 7, 39956; doi: 10.1038/srep39956 (2017) "Universal and reusable virus deactivation system for respiratory protection" B. Koch, I. Rubino, F.-S. Quan, B. Yoo, H. –J. Choi*, Materials, 9(8), 646 (2016) "Microfabrication for Drug Delivery" J. Kim, I. Rubino, J.-Y. Lee, H. –J. Choi*, Materials Research Express 3, 045019 (2016) "Application of Halloysite Nanotubes for Carbon Dioxide Capture" Y.C. Kim, S.H. Lee, W.H. Choi, H. –J. Choi, T.W. Goo, J.H. Lee, F.S. Quan, Journal of drug targeting, DOI:10.3109/1061186X.2016.1159213 (2016) "Microneedle delivery of trivalent influenza vaccine to the skin induces long-term cross-protection" H. –J. Choi, J. –M. Song, B. J. Bondy, R. W. Compans, S. –M. Kang, M. Prausnitz, PLoS One 10(7), e0134431 (2015) "Effect of osmotic pressure on the stability of whole inactivated influenza vaccine for coating on microneedles" M. –C. Kim, J. –W. Lee, H. –J. Choi, Y. –N. Lee, H. S. Hwang, J. Lee, C. Kim, J. S. Lee, C. Montemagno, M. R. Prausnitz, S. –M. Kang, Journal of Controlled Release 210, 208-216 (2015) "Microneedle patch delivery to the skin of virus-like particles containing heterologous M2e extracellular domains of influenza virus induces broad heterosubtic cross-protection" J. Patel, M. –C. Kim, V. F. Vartabediana, Y. –N. Lee, S. He, J. –M. Song, H. –J. Choi, S. Yamanaka, N. Amarama, A. Lukachera, C. Montemagno, R. W. Compans, S. –M. Kang, P. Selvaraja, Nanomedicine 11(5), 1097-1107 (2015) "Protein transfer-mediated surface engineering to adjuvantate virus-like nanoparticles for enhanced anti-viral immune responses" H. –J. Choi*, M. –C. Kim, S. –M. Kang, C. D. Montemagno*, Archives of Pharmacal Research 37(12), 1607-1616 (2014) “The osmotic stress response of split influenza vaccine particles in an acidic environment” H. –J. Choi*, C. D. Montemagno*, Materials 6(12), 5821-5856 (2013) “Recent progress in advanced nanobiological materials for energy and environmental applications” 97%ile Ranks 1st in Materials journal (as of 21st April 2014) H. –J. Choi*, T. J. Stazak, C. D. Montemagno*, Journal of Nanoparticle Research 15(10), 1-13 (2013) “Surface-dependent cytotoxicity on bacteria as a model for environmental stress of halloysite nanotubes” H. –J. Choi*, C. Ebersbacher, M. –C. Kim, S. –M. Kang, C. D. Montemagno*, PLoS One 8(6), e66316 (2013) “A mechanistic study on the destabilization of whole inactivated influenza virus vaccine in gastric environment” Highlighted as a key scientific article of Global Medical Discovery (June 28, 2013) H. –J. Choi*, C. Ebersbacher, F. S. Quan, C. D. Montemango*, Nanotechnology 24(5), 055603 (2013) “pH stability and comparative evaluation of ranaspumin-2 foam for application in biochemical reactors” Feature cover article / a key scientific article in June 2013 issue of Global Medical Discovery H. –J. Choi, B. Bondy, D. –G. Yoo, R. W. Compans, S. –M. Kang, M. R. Prausnitz, Journal of Controlled Release 166(2), 159-171 (2013). “Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles” H. –J. Choi*, C. Ebersbacher, N. V. Myung, C. D. Montemagno*, Journal of Nanoparticle Research 14(9), 1092:1-13 (2012) “Synthesis of nanoparticles with frog foam nest proteins” H. –J. Choi, D. –G. Yoo, B. Bondy, F. –S. Quan, R. W. Compans, S. –M. Kang, M. R. Prausnitz, Biomaterials 33(14), 3756-3769 (2012) “Stability of influenza vaccine coated onto microneedles” H. –J. Choi, D. Wendell, C. D. Montemagno, NanoBiotechnology 3(2), 66-75 (2007) “Advances in nano biotic/abiotic hybrid systems: Protein-based engineered devices” H. –J. Choi, C. D. Montemagno, IEEE Trans. on Nanotechnology 6(2), 171-176 (2007) “Light-driven hybrid bioreactor based on protein-incorporated polymer vesicles" H. –J. Choi, C. D. Montemagno, Nanotechnology 17, 2198-2202 (2006) “Biosynthesis within a bubble architecture” H. –J. Choi, J. Germain, C. D. Montemagno, Nanotechnology 17, 1825-1830 (2006) “Effect of different reconstitution procedures on membrane protein activities in proteopolymersomes” H. –J. Choi, C. D. Montemagno, Nano Letters 5, 2538-2542 (2005) “Artificial organelle: ATP synthesis from cellular mimetic polymersomes” H. –J. Choi, H. Lee, C. D. Montemagno, Nanotechnology 16, 1589-1697 (2005) “Toward hybrid proteo-polymeric vesicles generating a photo-induced proton gradient for biofuel cells” H. –J. Choi, E. Brooks, C. D. Montemagno, Nanotechnology 16, S143-149 (2005) “Synthesis and characterization of nanoscale biomimetic polymer vesicles and polymer membranes for bioelectronic applications” M. –J. Kim, H. –J. Choi, D. –H. Ko, J. –H. Ku, S. Choi, K. Fujihara, C. –W. Yang, Electrochemical and Solid State Letters 6(10), G122-125 (2003) “High thermal stability of Ni monosilicide from Ni-Ta alloy films on Si(100)” S. –W. Nam, J. –H. Yoo, S. Nam, H. –J. Choi, D. Lee, D. –H. Ko, J. H. Moon, J. –H. Ku, S. Choi, Journal of Non-Crystalline Solids 303, 139-143 (2002) “Influence of annealing condition on the properties of sputtered hafnium oxide” M. –J. Kim, H. –J. Choi, D. –H. Ko, J. –H. Ku, S. Choi, K. Fujihara, C. –W. Yang, Journal of the Korean Physical Society 40(4), 737-741 (2002) “Formation and thermal stability of Ti-capped Co-silicide from Co-Ta alloy films on (100) Si and polycrystalline silicon”