Jones, Sarah - University of Wolverhampton - Faculty of Science & Engineering

个人简介

Dr Sarah Jones is a Lecturer in Pharmacology and a member of the Molecular Pharmacology Research Group. For the past 15 years, Sarah’s research has focussed on Cell Penetrating Peptides as a means to reach and modulate biological events within the cell. The ability of Cell Penetrating Peptides to target numerous and previously elusive intracellular candidate sites for therapeutic interventions could offer unparalleled opportunities for drug development and expand the repertoire of novel “druggable” targets. With over 40 publications to date, numerous speaker invitations at International Symposia and co-editor of the book Bioactive Peptides, Sarah is now an established figure within the field of Cell Penetrating Peptides. Additionally, she has organized 3 International conferences including; a joint FEBS/Biochemical Society 4-day lecture course "Cell Penetrating Peptides" held at the Royal Society 2013, a Zing sponsored conference "Peptide Therapeutics 2012" and a Biochemical Society Focused Meeting "Cell Penetrating Peptides 2007.

研究领域

Cell Penetrating Peptide Technologies now provide a means of delivering previously impenetrable cargoes into the cell’s interior. Currently, Sarah’s endeavours encompass the design, synthesis and evaluation of cell penetrating peptides which target intracellular protein-protein interactions. Such investigations include identification of novel cryptic cell penetrating peptides within key signalling proteins and evaluation of their applicability as biological modulators (Bioportides) of apoptosis, tumour angiogenesis and Parkinson’s disease pathophysiology. The latter of which comprises a pilot study funded by the Michael J Fox Foundation, “Evaluation of LRRK2-derived Bioportides as Functional Protein Modulators and Potential Therapeutics”. Very recently, Sarah’s research has extended to the utility of cell penetrating peptides as novel site-specific intracellular delivery vectors into mammalian sperm. With the ability to deliver bioactive cargoes into the sperm’s interior, such a development now provides the research community with valuable tools to investigate and modulate fundamental processes of sperm physiology and pathophysiology.

近期论文

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Morris, J., Jones, S., Howl, J., Lukanowska, M., Lefievre, L. & Publicover, S. (2015) Cell penetrating peptides, targeting the regulation of store-operated 1 channels, slow decay of the progesterone-induced [Ca2+ ]i signal in human sperm. Molecular Human Reproduction. In press. Howl, J. & Jones, S. (2015) Cell penetrating peptide-mediated transport enables the regulated secretion of accumulated cargoes from mast cells. J. Control. Release 202, 108-117. Howl, J. & Jones, S. (2015) Insights into the molecular mechanisms of action of bioportides: a strategy to target protein-protein interaction. Expert Reviews in Molecular Medicine 17, e1 doi:10.1017/erm.2014.24. Lukanowska, M., Howl, J. & Jones, S. (2013) Bioportides: bioactive cell-penetrating peptides that modulate cellular dynamics. Biotechnology Journal 8, 918-930. Mehta, A., Shervington, A., Howl, J., Jones, S., Shervington, L. (2013) Can RNAi-mediated hsp90 αknockdown in combination with 17-AAG be a therapy for glioma? FEBS Open Bio 3, 271-278. http://dx.doi.org/10.1016/j.fob.2013.06.002. Jones, S., Lukanowska, M., Suhorutsenko,J., Oxenham, S., Barratt, C., Publicover, S., Copolovici, D.M., Langel,Ü. and Howl, J. (2013) Intracellular translocation and differential accumulation of cell penetrating peptides into bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility. Human Reproduction 28, 1874-1889 Eriste, E., Kurrikoff, K., Suhorutšenko, J., Oskolkov, N., Copolovici, Dana, Jones, S., Howl, J., Laakkonen, P. and Langel, U. (2012) Peptide-based glioma-targeted drug delivery vector gHoPe2. Biocongugate Chemistry 24, 305-313