Rahman, Ayesha Sabah - University of Wolverhampton - Faculty of Science & Engineering

个人简介

After completing her undergraduate degree in Pharmacy, Ayesha studied for a Masters in Applied Biomolecular Technology at the University of Nottingham which was followed by a PhD at the University of Birmingham investigating the molecular pathways in microbial systems which produce medicinally important products such as antibiotics. Having completed her doctoral thesis, Ayesha worked as a Post-doctoral Research Fellow at the University of Birmingham investigating the transcriptional and metabolite response of pathogenic E.coli to acid stress as encountered in the GI tract.

研究领域

Application of “omic” technologies to research antimicrobial compounds Evaluation of genomic drug transporter response to commonly prescribed antibiotics Determining mechanisms of antimicrobial transport and inhibition Genetic engineering of metabolic pathways to produce “unnatural” natural products Identification of potential drug targets by studying stress response in microbes Studying the genomic response of host pathogen interaction

近期论文

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Russell C, Rahman AS and Mohammed AR (2013). Application of genomics, proteomics and metabolomics in drug discovery, development and clinic. Therapeutic Delivery Mar;4(3):395-413. Turan N, Kalko S, Stincone A, Sabah A, Howlett K, Curnow SJ, Rodriguez DA, Cascante M, O’Neill L, Egginton S, Roca J and Falciani F (2012). A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease. PLoS Comput Biol. Sep;7(9):1-16 Stincone A, Daudi N, Rahman AS, Antczak P, Henderson I, Cole J, Johnson MD, Lund P, Falciani F.(2011). A systems biology approach sheds new light on Escherichia coli acid resistance. Nucleic Acids Research 39(17):7512-28. Khan S, ElShaer A, Rahman AS, Hanson P, Perrie Y, Mohammed AR (2011). Systems biology approach to study permeability of paracetamol and its solid dispersion. International Journal of Pharmaceutics 417(1-2):272-9. Khan S, ElShaer A, Rahman AS, Hanson P, Perrie Y, Mohammed AR(2011). Genomic evaluation during permeability of indomethacin and its solid dispersion. Journal of Drug Targeting. 19(8):615-23. Shields JA, Rahman AS, Arthur CJ, Crosby J, Hothersall J, Simpson TJ, Thomas CM. (2010). Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster. ChemBioChem 11(2):248-55. Wu J, Hothersall J, Mazzetti C, O'Connell Y, Shields JA, Rahman AS, Cox RJ, Crosby J, Simpson TJ,Thomas CM, Willis CL (2008). In vivo mutational analysis of the mupirocin gene cluster reveal labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism. Chembiochem. 6;9(9):1500-8. Hothersall J, Wu J, Rahman AS, Shields JA, Haddock J, Johnson N, Cooper SM, Stephens ER, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM (2007). Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A. Journal of Biological Chemistry 282(21):15451-61. Cooper, S. M., Laosripaiboon, W., Rahman, AS., Hothersall, J., El-Sayed, A. K., Winfield, C., Crosby, J., Cox, J. R., Simpson, T. J. & Thomas, C.M (2005). Shift to Pseudomonic acid B production in Pseudomonas fluorescens NCIMB10586 by Mutation of Mupirocin Tailoring Genes mupO, mupU and mupV. Chemistry & Biology; 12 (7): 825-833. Rahman, AS., Hothersall, J., Crosby, J., Simpson, T. J. & Thomas, C. M (2005).Tandemly duplicated acyl carrier proteins which increase polyketide antibiotic production can apparently function either in parallel or in series. Journal of Biological Chemistry.;280: 6399 - 6408.