Kirkham, Paul - University of Wolverhampton - Faculty of Science & Engineering

个人简介

Professor Kirkham joined the University of Wolverhampton in 2013 from Imperial College London. In 2014 he was made Professor of Cell biology and now heads up the Respiratory disease research group. Professor Kirkham completed his first degree in Biochemistry at Leeds University in 1985 and went on to receive a PhD in Biochemistry from Surrey University. In 1989 he joined the Dept of Molecular and Cellular Immunology at the MRC National Institute for Medical Research as a postdoctoral fellow investigating mechanisms of B and T cell activation. Then in 1991, he moved to the BBSRC Institute for Animal Health to continue his research into molecular mechanisms regulating T cell activation and senescence. In 1998 he moved into industry and joined Novartis, where as a Lab Head in the Division of Immunology he led a team undertaking drug discovery research for respiratory disease. He returned to academia in 2008 following the award of a Royal Society Industry Fellowship and joined the staff at the National Heart and Lung Institute as a senior fellow within Imperial College London. Over the next 5 years he continued his research into the pathophysiology of respiratory disease, such as COPD where he identified a novel mechanism that may explain the onset of lung destruction in COPD as well as discovering and patenting a biomarker to aid diagnosis and help patient stratification with this disease. He is currently the editor in chief for the Journal of Inflammation and the current elected secretary of the ‘Airways diseases & pharmacology’ group within the European Respiratory Society, as well as the treasurer for the British Inflammation Research Association. He is an external examiner for St Georges Hospital, University of London and a Fellow of the Higher Education Academy. He has supervised and examined a number of PhD students and has published extensively over his career. He is also a reviewer for numerous journals as well as research grant bodies. He has organised, chaired and presented at several national & international conferences and is currently on the organisation committee as well as being the finance director for the 2017 World Congress on Inflammation. Finally he is the founder and CSO of a spin-off biotech company from his research.

研究领域

His current research involves investigating the role of oxidative and carbonyl stress on cell function and immunity in chronic inflammatory diseases, such as COPD, and more recently in ageing. It utilises a multidisciplinary approach drawing on molecular, pharmacological and proteomic techniques, in order to translate clinical observations into mechanisms of disease pathogenesis. Recent findings in his lab would suggest a possible role for a number of factors in disease pathogenesis as well as linkage to associated comorbidities with COPD. In collaboration with key opinion leaders in respiratory disease research from the UK, Europe and the USA he his translating his clinical findings into mechanistic models of COPD.

近期论文

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Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Andò F, Speciale G, Kilty L, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH. (2015) Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD. Am J Physiol Lung Cell Mol Physiol. 309(10):L1112-23 Fletcher ME, Boshier PR, Wakabayashi K, Keun HC, Smolenski RT, Kirkham PA, Adcock IM, Barton PJ, Takata M, Marczin N. (2015) Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism. Am J Physiol Lung Cell Mol Physiol. 308(12):L1274-85 Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM (2015) Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease: COPDMAP. J Allergy Clin Immunol. In press Caramori G, Kirkham P, Barczyk A, Di Stefano A, Adcock I.(2015) Molecular pathogenesis of cigarette smoking-induced stable COPD. Ann N Y Acad Sci. 1340: 55-64 Khan YM, Kirkham P, Barnes PJ, Adcock IM. (2014) Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells. PLoS One. 9(4): e95051 Kirkham PA, Whiteman M, Winyard PG, Caramori G, Gordon F, Ford P, Barnes PJ, Adcock IM and Chung KF (2014) Impact of theophylline/corticosteroid combination therapy on sputum H2S levels in patients with COPD. European Respiratory Journal 43; 1504-6 Weigman CH, Li F, Clark CJ, Jazrawi E, Kirkham P, Barnes PJ, Adcock IM & Chung KF. (2014) A comprehensive analysis of oxidative stress in the ozone induced lung inflammation mouse model. Clin Sci (Lond). 126; 425-40