个人简介

Will is originally from Coppull, near Chorley in Lancashire (UK). He studied chemistry at the University of Oxford, and remained there to complete his Ph.D. studies in the group of Prof. Jeremy Robertson. He completed his Ph.D. in 2010 and then began work at the University of York, first as a postdoctoral research associate in the group of Prof. Richard J. K. Taylor, before being appointed to a Research and Teaching Fellowship in 2013. He has recently been awarded a Leverhulme Trust Early Career Fellowship to develop new procedures to synthesise functionalised macrocycles. His current research interests include the construction of diverse spirocyclic scaffolds, cascade reactions, macrocylisation and total synthesis. He now lives in York with his wife Hayley and two children Billy and Catherine.

研究领域

Synthetic chemistry, macrocycles, spirocycles, natural products

My group is interested in the development of new methods for the synthesis of functionalised, complex molecules with applications. Current Research Interests: Macrocycle Synthesis, Direct Imine Acylation, spirocyclisation, C–H activation, alkyne activation, copper catalysis, rhodium catalysis, asymmetric synthesis, target synthesis. More deatils on current projects are included below:

近期论文

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Ring expansion approach to medium-sized lactams and analysis of their medicinal lead-like properties L. G. Baud, M. A. Manning, H. L. Arkless, T. C. Stephens, W. P. Unsworth, Chem. Eur. J. 2017, 23, 2225. Catalytic Dearomatization Approach to Quinolizidine Alkaloids:Five Step Total Synthesis of (±)-Lasubine II M. J. James, N. D. Grant, Peter O’Brien, R. J. K. Taylor, W. P. Unsworth, Org.Lett. 2016, 18, 6256−6259. Preparation and Reactions of Indoleninyl Halides: Scaffolds for the Synthesis of Spirocyclic Indole Derivatives J. T. R. Liddon, A. K. Clarke, R. J. K. Taylor, W. P. Unsworth, Org. Lett. 2016, 18, 6328−6332 Silica-supported silver nitrate as a highly active dearomatising spirocyclisation catalyst: synergistic alkyne activation by silver nanoparticles and silica A. K. Clarke, M. J. James, P. O’Brien, R. J. K. Taylor, W. P. Unsworth, Angew. Chem. Int. Ed. 2016, 55, 13798–13802 Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor M. J. James, P. O’Brien, R. J. K. Taylor, W. P. Unsworth, Angew. Chem. Int. Ed. 2016, 54, 9671–9675 Catalyst-driven scaffold diversity: selective synthesis of spirocycles, carbazoles and quinolines from indolyl ynones J. T. R. Liddon, M. J. James, A. K. Clarke, P. O'Brien, R. J. K. Taylor, W. P. Unsworth, Chem. Eur. J. 2016, 22, 8777–8780. From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis S.J. Chambers, G. Coulthard, W. P. Unsworth, P. O’Brien, R. J. K. Taylor, Chem. Eur. J. 2016, 22, 6496–6500. Synthesis of Spirocyclic Indolenines M. J. James, P. O’Brien, R. J. K. Taylor, W. P. Unsworth, Chem. Eur. J. 2016 22, 2856–2881. The Synthesis of Structurally Diverse Macrocycles By Successive Ring Expansion C. Kitsiou, J. J. Hindes, P. I’Anson, P. Jackson, T. C. Wilson, E. K. Daly, H. R. Felstead, P. Hearnshaw, W. P. Unsworth, Angew. Chem. Int. Ed. 2015, 54, 15794 –15798. Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles M. J. James, R. E. Clubley, K. Y. Palate, T. J. Procter, A. C. Wyton, P. O’Brien, R. J. K. Taylor, W. P. Unsworth, Org. Lett. 2015, 17, 4372. Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds M. J. James, J. Cuthbertson, P. O’Brien, R. J. K. Taylor, W. P. Unsworth, Angew. Chem. Int. Ed. 2015, 54, 7640. A One-Pot C–H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones. M G Lloyd, R J K Taylor and W P Unsworth, Org. Lett., 2014, 16, 2772. Direct Imine Acylation for Molecular Diversity in Heterocyclic Synthesis. W P Unsworth, G Coulthard, C Kitsiou, and R J K Taylor, J. Org. Chem., 2014, 79, 1368. ‘Upenamide: trials and tribulations. W P Unsworth and R J K Taylor, Org. Biomol. Chem., 2013, 11, 7250. Total Synthesis of Spirobacillene A. W P Unsworth, J D Cuthbertson and R J K Taylor, Org. Lett., 2013, 15, 3306. An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine. W P Unsworth, C Kitsiou and R J K Taylor, Org. Lett., 2013, 15, 3302. Direct Imine Acylation: Synthesis of the Proposed Structures of ‘Upenamide. W P Unsworth, K A Gallagher, M l Jean, J P Schmidt, L J Diorazio and R J K Taylor, Org. Lett., 2013, 15, 262. Direct Imine Acylation: Rapid Access to Diverse Heterocyclic Scaffolds. W P Unsworth, C Kitsiou and R J K Taylor, Org. Lett., 2013, 15, 258.