研究领域

The total synthesis of compounds of biological importance: design and development of new synthetic methods

The Design and Development of New Synthetic Methods We are involved in two main areas of research which are often interlinked. The first is the synthesis of natural product and related compounds of biological interest. In order to carry out efficient target molecule synthesis, it is often necessary to develop new synthetic methodology. This leads on to the second main research area, the development of new synthetic transformations, particularly those using organometallic and organosulfur reagents. We are also interested in the design of new telescoped and cascade organic transformations (including tandem oxidation processes, TOP) with environmental benefits.

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Organometallic Routes to Novel Steroids Containing Heterocyclic C-17 Side-Chains. L Vitellozzi, G D McAllister, T Genski, R J K Taylor, Synthesis 2016, 48, 48. A selective C–H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products. M G Lloyd, M D'Acunto, R J K Taylor, W P Unsworth, Org. Biomol. Chem., 2016, Advance Article Total Synthesis and Stereochemical Revision of Phacelocarpus 2-Pyrone A. T O Ronson, M Burns, M H H Voelkel, K Evans, J M Lynam, R J K Taylor, I J S Fairlamb, Chem: Eur, J., 2015, online. Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles. M J James, R E Clubley, K Y Palate, T J Procter, A C Wyton, P O'Brien, R J K Taylor, W P Unsworth, Org. Lett., 2015, 17, 4372. Synthetic Studies towards the Africanane Sesquiterpenes via the Cope Rearrangement of gem-Dimethyl-Substituted Divinyl Cyclopropanes. J D Osler, W P Unsworth, R J K Taylor, Synlett, 26, online. Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds. M J James, J D Cuthbertson, P A O'Brien, R J K Taylor, W. P. Unsworth, Angew. Chemie Int. Ed., 2015, 54, 7640. α-Alkylidene-γ-butyrolactone synthesis via one-pot C–H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B. M G Lloyd, M D'Acunto, R J K Taylor, W P Unsworth, Tetrahedron, 2015, 71, 7107. Substrate scope in the copper-mediated construction of bis-oxindoles via a double C-H/Ar-H coupling process. P Drouhin, T E Hurst, A C Whitwood, R J K Taylor, Tetrahedron, 2015, 71, 7124. The total synthesis of (+)-elaeokanidine A: natural product or isolation artefact? J D Cuthbertson, W P Unsworth, C L Moody, R J K Taylor, Tetrahedron Lett., 2015, 56, 3123. Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids. G Coulthard, W P Unsworth, R J K Taylor, Tetrahedron Lett., 2015, 56, 3113.