研究领域

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Transition metal and main group chemistry

New Catalysts for the Activation of Pyridine using Pyridylidene Intermediates We have recently developed new methods for the direct C-H functionalisation of pyridine and its derivatives. Using half-sandwich ruthenium complexes, such as 1 we have demonstrated that it is possible to formally insert an alkyne into the C-H bond of pydridine (Scheme 1).1 The key mechanistic step in this process revolves around the formation of a remarkable class of ligands, pyridylidenes, which are an interesting class of metal carbene complexes. We have been able to isolate complexes containing these ligands (2) and (in collaboration with Dr John Slattery) used density functional theory to show that pyridylidene ligands are indeed key intermediates in the C-H bond activation and C-C bond formation steps.