研究领域

Nuclear Magnetic Resonance (NMR) Spectroscopy

My research focuses on the development of new nuclear magnetic resonance (NMR) methods with a particular focus on the use of hyperpolarisation to open up new and exciting applications for this technique. Magnetic resonance (MR) is an invaluable tool for applications ranging from chemical analysis to clinical diagnosis. The power of MR lies in the wealth of molecular-level information available and the selectivity and control provided by the use of radio-frequency irradiation and magnetic field gradients to tune the evolution of the MR signals. In magnetic resonance, the signal arises from the difference in population between nuclear spin states in the presence of an external magnetic field. Even at the highest available magnetic field (currently 23.5 T), this population difference is so small that only 1 in every 12,000 nuclear spins contribute to the observed signal. Given this inherent low sensitivity, the success of nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) is quite remarkable.

近期论文

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Macroscopic Nuclear Spin Diffusion Constants of Rotating Polycrystalline Solids from First-Principles Simulation. M E Halse, A Zagdoun, J-N Dumez and L Emsley, Journal of Magnetic Resonance, 2015, 254, 48-55. 10.1016/j.jmr.2015.02.016 Direct observation of hierarchical protein dynamics. J R Lewandowski, M E Halse, M Blackledge and L Emsley, Science, 2015, 348, 578-58. 10.1126/science.aaa6111 Photochemical pump and NMR probe: Chemically created NMR coherence on a microsecond time scale. O Torres, B Procacci, M E Halse, R W Adams, D Blazina, S B Duckett, B Eguillor, R A Green, R N Perutz and D C Williamson, J. Am. Chem. Soc., 2014, 136, 10124- 0131. 10.1021/ja504732u High-resolution 1H solid-state NMR spectroscopy using windowed LG4 homonuclear dipolar decoupling. M E Halse, J Schlagnitweit and L Emsley, Isr. J. Chem., 2014, 54, 134-146. Improved phase-modulated homonuclear dipolar decoupling for solid-state NMR spectroscopy from symmetry considerations. M E Halse and L Emsley, J. Phys.Chem. A., 2013, 117, 5280-5290. Quasi-equilibria in reduced Liouville spaces. M E Halse, J-N Dumez and L Emsley, J. Chem. Phys., 2012, 136, 224511. A common theory for phase-modulated homonuclear decoupling in solid-state NMR. M E Halse, and L Emsley, Phys. Chem. Chem. Phys., 2012, 14. 9121-9130. A first-principles description of proton-driven spin diffusion. J-N Dumez, M E Halse, M Butler and L Emsley, Phys. Chem. Chem. Phys., 2012, 14, 86-89. Quantitative analysis of Earth's field NMR spectra of tightly coupled heteronuclei.Quantitative analysis of Earth's field NMR spectra of tightly coupled heteronuclei. M E Halse, P T Callaghan, B Feland and R E Wasylishen, J Magn. Reson., 2009, 200, 88-94. A dynamic nuclear polarisation strategy for multidimensional Earth's field NMR spectroscopy. M E Halse and P T Callaghan, J. Magn. Reson., 2008, 195, 62-168.