个人简介

Martin Fascione received his Ph.D. from the University of Leeds in 2009, working under the tutelage of W. Bruce Turnbull on the stereoselective synthesis of 1,2-cis-glycosides. Following a postdoctoral period in Leeds, Martin was awarded a Marie Curie International Outgoing Fellowship to study the mechanisms of carbohydrate processing enzymes with Prof. Steve Withers, FRS, at the University of British Columbia in Vancouver, Canada (2012-2013) and Prof. Gideon Davies, FRS, FMedSci, at the University of York, UK (2013-2014). In August 2014 he took up a lectureship in the York Structural Biology Laboratory, within the Department of Chemistry.

研究领域

Chemical glycobiology, synthetic carbohydrate chemistry, chemical/enzymatic modification of proteins

bioorthogonal chemistry exploration of rare sugars in bacterial infections mechanisms of stereoselective glycosylation chemical and enzymatic modification of proteins chemoenzymatic and automated oligosaccharide synthesis solid phase peptide synthesis unnatural amino acid mutagenesis Carbohydrates are integral in a number of important biological processes including tumour metastasis, bacterial and viral recognition, and the immunological response. Following the sequencing of the human genome over a decade ago, breakthroughs in the field have stimulated a glycoscience research boom which has undoubtedly yielded stunning results but also served to highlight how little we still understand about carbohydrates in all domains of life. The Fascione group studies carbohydrates at the interface between chemistry and biology- a field commonly termed ‘chemical glycobiology’. Our focus is on deciphering the roles that carbohydrates play in the etiology of disease and applying this knowledge in the development of innovative new therapeutics. To achieve this goal we develop new methods for bioorthogonal chemistry and protein bioconjugation, using small molecule organocatalysts and an interdisciplinary toolkit of techniques including synthetic and automated carbohydrate chemistry, solid phase peptide synthesis (SPPS), the enzymatic and chemical modification of proteins, unnatural amino acid mutagenesis and molecular enzymology.

近期论文

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Site-selective incorporation and ligation of protein aldehydes Spears, R. J, *Fascione, M. A, Org Biomol. Chem, 2016, 14, 7622-7638. Highlighted as a "Hot Article" Compact, polyvalent mannose-quantum dots as sensitive, ratiometric FRET probes for multivalent protein-ligand interactions Guo, Y., Sakonsinsiri, C, Nehlmeier, I, Fascione, M. A., Zhang. H; Pohlman, S.; Turnbull, W. B.; Zhou, D. Angew. Chem. Int. Ed., 2016, 55 (15), 4738-4742 Highlighted as a VIP (Very Important Paper), and on back cover. Mechanistic investigations into the application of sulfoxides in carbohydrate synthesis *Fascione, M. A.; Brabham, R.; Turnbull, W. B., Chem. Eur. J. 2015, 21, 1-14. Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries Mahon, C. S.; Fascione, M. A.; Sakonsinsiri, C.; McAllister, T. E.; Turnbull, W. B.; Fulton, D. A.; Org. Biomol. Chem., 2015, 13, 2756-2761. A Protein-Based Pentavalent Inhibitor of the Cholera Toxin B-Subunit T R Branson, T E McAllister, J Garcia-Hartjes, M A Fascione, J F Ross, S L Warriner, T Wennekes, H Zuilhof and W B Turnbull, Angew. Chem. Int. Ed. 2014, 53 (32), 8323–8327. Efficient N-terminal labelling of proteins by use of Sortase. D Williamson, M A Fascione, M E Webb, and W B Turnbull, Angew. Chem. Int. Ed. 2012, 51, 9377-9380