研究领域

Transition metals in synthesis, catalysis and chemical biology: reactivity, mechanism and applications

Our core interests are in the development and application of transition metal chemistry in catalysis and synthetic chemistry. We are particularly interested in metal catalyst design and mechanistic understanding, especially in C-H and C-X activation processes, which we have a strong track record in. Our work has links to chemical biology. Organometallic therapeutic agents such as carbon monoxide releasing molecules and fluorescent heteroaromatic compounds (purines, 2-pyrones and tryptophan derivatives) are of interest to the research group. We use natural product synthesis as a sharpening tool for our new catalysts and catalytic processes.

近期论文

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C-H activation and Pd nanoparticles Chem. Commun. 2015, 51, 16289. Catalysis with Au-NHC and Cu-NHC complexes Chem. Commun. 2016, 52, 5057. Total synthesis of phacelocarpus 2-pyrone A - application of AsCat Chem. Eur. J. 2015, 21, 18905. π-Acidic alkene ligand effects at Pd J. Am. Chem. Soc. 2013, 135, 8388. On impurities in Pd(OAc)2/nitrite linkage isomerisation at Pd Angew. Chem. Int. Ed. 2015, 54, 10415; Chemical Science, 2012, 3, 1656. Pd-nanoparticles in Suzuki cross-couplings Angew. Chem. Int. Ed. 2010, 49, 1820. Mechanistic studies in adenosine C-H activation J. Org. Chem. 2009, 74, 5810. C-H bond activation in tryptophan containing compounds and involvement of Pd nanoparticles Chem. Commun. 2014, 50, 3052. Imidate (pseudohalide) ligand effects in Pd-catalysed cross-couplings Chem. Commun. 2015, 51, 3466. Pericyclic processes, 6π-electrocylization and Pauson-Khand chemistry CrystEngComm 2012, 14, 5564; J. Org. Chem. 2011, 76, 5320 and Org. Biomol. Chem. 2008, 6, 4523. CO-Releasing Molecules Chem. Eur. J. 2014, 20, 15061 (lead reference on TryptoCORM). Emergence of Palladium(IV) Chemistry in Synthesis and Catalysis Chem. Rev. 2010, 110, 824.