个人简介

Gideon Davies received his PhD from the University of Bristol in 1990, and went on to postdoctoral research at EMBL Hamburg and CNRS Grenoble. In 1996 he received a Royal Society University Research Fellowship to work on Carbohydrate-Active Enzymes. He was made a Professor of the University of York in 2001. He has won many awards including the 2016 iChemE Global Energy award, the 2015 Davy Medal of the Royal Society, the 2014 Khorana Prize of the Royal Society of Chemistry, and the 2010 Gabor Medal of the Royal Society. Gideon was elected a a Fellow of The Royal Society in 2010, and as a member of the European Molecular Biology Organization the same year. He was also elected a Fellow of the Academy of Medical Sciences in 2014. Gideon Davies was made a Royal Society Ken Murray Research Professor in 2016.

研究领域

Structural enzymology and carbohydrate chemistry

My research spans the disciplines of Chemistry and Biology, with a focus on the structural enzymology and chemical biology of proteins involved in the synthesis and degradation of carbohydrates. Current projects include: the enzyme discovery and the enzymology of biomass conversion, focusing on the human intestinal microbiota and on fungal and bacterial lytic polysaccharide monooxygenases; the O-GlcNAc modification and its role in neurodegeneration; glycan synthesis and degradation in health and disease, probing cancer viral invasion and lysosomal storage diseases; opiate biosynthesis.

近期论文

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Complex pectin metabolism by gut bacteria reveals novel catalytic functions Ndeh et al. Nature, 2017, advanced online publication doi:10.1038/nature21725 Structural and functional insight into human O-GlcNAcase Roth et al., Nature Chem Biol, 2017, advanced online publication doi:10.1038/nchembio.2358 Detection of Active Mammalian GH31 α‑Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes Jiang et al., ACS Central Science, 2016 2, 351-358 The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases Frandsen et al., Nature Chem Biol, 2016, 12, 298-303 YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids Speciale et al., Nature Chem Biol, 2016, 12, 215-217 Structural characterization of human heparanase reveals insights into substrate recognition Wu et al., Nature Struct Mol Biol 2015, 22, 1016-1022 Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism Cuskin et al., Nature, 2015, 517, 165–169 A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes J Larsbrink et al., Nature 2014, 506, 498-502