个人简介

Education Ph.D. Pennsylvania University (Prof. Steven M. Weinreb) Aug. 2004 M.S., Seoul National University (Prof. Deukjoon Kim), Feb. 1998 B.S. Seoul National University, Feb. 1996 Career Associate Professor, Department of Chemistry, KAIST (2012.3-present) Assistant Professor, Department of Chemistry, KAIST (2009.2-2012.2) Principal Scientist, GlaxoSmithKline (GSK) in USA, Postdoc, Harvard University (Prof. E. J. Corey) Academes and Society ACS member KCS member Awards *Asian Core Program (ACP) Lectureship Award, Taiwan & Malaysia (2012) *1st Young Organic Chemist Award, Div. of Organic Chemistry, KCS (2012) * Best Researcher Award, Department of Chemistry, KAIST (2012) * Thieme Chemistry Journal Award, Thieme Publishers (2012) * Asian Core Program (ACP) Lectureship Award, Japan (2011) * Best Lecturer Award, College of Natural Science, KAIST (2011) * Best Lecturer Award, Department of Chemistry, KAIST (2010) * Silver impact award, GSK (2008) * Bronze impact award, GSK (2007)

研究领域

Organic/Medicinal Chemistry

Our research interests revolve the synthesis of complex molecules of importance in biology and human medicine, and translational research aimed at developing drugs for medical needs. Research topics * Development of New Reactions & Organic Synthesis * Advanced Medicinal Chemistry * Chemical Biology & Bioorganic Chemistry * Computer-aided & Fragment Based Rational Drug Design

近期论文

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"Rh(III) and Ru(II)-Catalyzed Site-Selective C–H Alkynylation of Quinolones" Kang, D.; Hong, S. Org. Lett. 2015, in press. "Rh(I)-Catalyzed Site-Selective Decarbonylative Alkenylation and Arylation of Quinolones under Chelation Assistance" Kwon, S.; Kang, D.; Hong, S. Eur. J. Org. Chem. 2015, in press. "Rh(III)-Catalyzed Direct C–H/C–H Cross-Coupling of Quinones with Arenes Assisted by Directing Group: Identification of Carbazole Quinones as GSKb Inhibitors" Moon, Y.; Jeong, Y.; Kook, D.; Hong, S. Org. Biomol. Chem. 2015, 13, 3918. "Efficient Synthesis of Frutinone A and Its Derivatives via Palladium-Catalyzed C-H Activation/Carbonylation" Shin, Y.; Yoo, C.; Moon, Y.; Lee, Y.; Hong, S. Chem.-Asian J. 2015, 10, 878. “HS-543 Induces Apoptosis of Imatinib-Resistant Chronic Myeloid Cells with T315I Mutation" Kim, S.-J.; Jung, K. H.; Yan, H. H., Son, M.-K.; Fang, Z.; Ryu, Y.-L.; Lee, H.; Kim, J.; Lee, S.; Hong, S.*; Hong, S.-S.* ONCOTARGET 2015, 6, 1507-1518. "Computational Design and Discovery of Nanomolar Inhibitors of IκB Kinase b" Park, H.; Shin, Y.; Choe, H.; Hong, S. J. Am. Chem. Soc. 2015, 137, 337. “Anticancer Activity of HS-527, a Novel Inhibitor Targeting PI3-Kinase in Human Pancreatic Cancer Cells” Ryu, Y.-L.; Jung, K. H.; Son, M. K.; Yan, H. H.; Kim, S. J.; Shin, S.; Hong, S.*; Hong, S.-S.* Cancer Lett. 2014, 353, 68. "HS-133, a Novel Fluorescent Phosphatidylinositol 3-Kinase Inhibitor as a Potential Imaging and Anticancer Agent for Targeted Therapy" Lee, J.-H.; Jung, K. H.; Lee, H.; Yun, S.-M., Son, M.-K.; Ahn, S.-H.; Lee, S.; Kim, D.; Hong, S.*; Hong, S.-S.* ONCOTARGET 2014, 5, 10180. "Copper-Mediated Cross-Coupling Approach for the Synthesis of 3-Heteroaryl Quinolone and Related Analogues" Shin, S.; Kim, Y.; Kim, K.; Hong, S. Org. Biomol. Chem. 2014, 12, 5719. “HS-104, a PI3K inhibitor, enhances anticancer efficacy of gemcitabine in pancreatic cancer” Jung, K. H.; Yan, H. H.; Fang, Z.; Son, M. K.; Lee, H.; Hong, S.; Hong, S.-S. Int. J. Oncol. 2014, 45, 311-321. "AgSbF6-Controlled Diastereodivergence in Alkyne Hydroarylation: Facile Access to Z- and E-Alkenyl Arenes" Min, M.; Kim, D.; Hong, S. Chem. Commun. 2014, 50, 8028. "Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain" Lim, K.; Kim, M.; Lee, M.-K.; Ko, J.; Hong, S.; Choi, B.-S. Int. J. Biochem. Cell Biol. 2014, 53, 237. "Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors" Lee, S.; Lee, H.; Kim, J.; Lee, S.; Kim, S. J. ; Hong, S.-S.; Hong, S. J. Med. Chem. 2014, 57, 6428. “HS-438, a New Inhibitor of Imatinib-Resistant BCR-ABL T315I Mutation in Chronic Myeloid Leukemia” Yun, S.-M., Jung, K. H.; Kim S. J.; Fang, Z. H.; Son, M. K.; Yan, H. H.; Lee, H.; Kim, J.; Shin, S.; Hong, S.*; Hong, S.-S.* Cancer Lett. 2014, 348, 50. “Synthesis of Heterocyclic-Fused Benzopyrans via the Pd(II)-Catalyzed C–H Alkenylation/C–O Cyclization of Flavones and Coumarins” Kim, Y.; Moon, Y.; Kang, D.; Hong, S. Org. Biomol. Chem. 2014, 12, 3413. “Selective and Potent Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinases” Jeong, Y.; Kwon, D.; Hong, S. Future Med. Chem. 2014, 6, 737. “Structure-based de novo design and identification of D816V mutant-selective c-KIT inhibitors” Park, H.; Lee, S.; Lee, S.; Hong, S. Org. Biomol. Chem. 2014, 12, 4644. "One-Pot Dehydrogenative Aromatization and Ortho-Functionalization Sequence of N-Acetyl Enamides" Kim, J.; Moon, Y.; Lee, S. Hong, S. Chem. Commun. 2014, 50, 3227. “Virtual Screening and Biochemical Evaluation to Identify New Inhibitors of Mammalian Target of Rapamycin (mTOR)” Park, H.; Choe, H.; Hong, S. Bioorg. Med. Chem. Lett. 2014, 24, 835.