研究领域

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Molecular mechanisms of bacterial pathogenesis The success of a bacterial species depends on its ability to grow and survive in a changing and potentially hostile environment. This requires adaptation at both the single cell and population level. We are particularly interested in understanding how behavior of bacterial populations is underpinned by phenotypic heterogeneity. We furthermore apply our expertise to developing and understanding mechanisms of action of novel antimicrobial therapies. We combine molecular biology and genetic approaches with genomics, immunology and modeling, and collaborate with physicists, mathematicians, biochemists, and clinical researchers internal and external to the University as needed to progress our science. To illustrate these research interests of the MvdW lab, some key research questions and associated research projects in the MvdW lab are outlined below. An aspect of bacterial populations that is only beginning to be fully appreciated is the heterogeneity of single cells in clonal populations. This heterogeneity raises a multitude of questions of broad significance. How does this heterogeneity arise, which processes are affected by this, and what is the overall effect on the success of the population? Our aim is to shed light on the contribution of population heterogeneity to the strategies bacteria use to survive, prosper, and evolve.