Ungar, Daniel - University of York - Department of biology

个人简介

Career 2016 - Senior Lecturer Department of Biology, University of York 2007 - 2016 Lecturer Department of Biology, University of York 2000 - 2007 Post-doc Princeton University, USA 1999 PhD in Biochemistry MPI of Biophysics/University of Frankfurt, Germany 1995 MSc in Chemistry Eötvös Loránd University of Budapest, Hungary

研究领域

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The diversity of eukaryotic glycan structures is produced by a large number of Golgi localized glycosylation enzymes. The precise localization of these enzymes to different Golgi cisternae is essential for accurate glycan synthesis. We are interested in the vesicular transport processes that sort resident enzymes to their cisternal destinations. The main goal of our group is to characterize the molecular mechanisms of vesicle targeting and its influence on glycosylation homeostasis in the secretory pathway. For this we focus on the conserved-oligomeric-Golgi (COG) vesicle targeting complex, whose mutations have been found to cause congenital glycosylation disorders in humans.