Sweeney, Sean T - University of York

个人简介

Career 2015 - Reader Department of Biology, University of York 2004 - 2015 Lecturer Department of Biology, University of York 2000 - 2004 Wellcome Trust Prize Travelling Fellow University of California, San Francisco 1996 - 1999 Darwin College Research Fellow University of Cambridge 1996 PhD University of Cambridge 1991 MPhil University of Leicester 1987 BSc Staffordshire University

研究领域

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My research centres on the role of the endosome in regulating signals controlling synapse growth. Appropriate regulation of synaptic growth is a key mechanism in regulating the fidelity of synaptic communication. We work with the larval neuromuscular junction of Drosophila as a model glutamatergic synapse to identify endosomal related signaling events occurring in human pathological conditions. Many neurodegenerative diseases show abnormal function of endosomal compartments. My previous work has suggested that in one form of neurodegenerative disease, a childhood dementia, endosomal perturbation leads to an excessive growth of the synapse most likely due to the failure to regulate growth signals appropriately. Using this model we have identified oxidative stress as a major signal driving synapse overgrowth. We also study a form of Frontotemporal Dementia (FTD) that has a perturbed endosome. We have used our Drosophila model of FTD to identify factors regulating progression of the disease and we are now building up a picture of the cellular events happening in synapses when they are affected by this condition.