Southgate, Jenny - University of York

个人简介

Career 1999 - Professor of Molecular Carcinogenesis & Director of the Jack Birch Unit of Molecular Carcinogenesis Department of Biology, University of York 1993 - 1999 Head of ICRF Group 'Biology of Normal and Malignant Epithelial Cells' Cancer Medicine Research Unit, University of Leeds 1990 - 1999 Research Fellow, then Senior then Principal Research Fellow Cancer Medicine Research Unit, University of Leeds 1989 PhD University of Leeds 1983 GI Biol (2:1 Hons) Biochemistry Institute of Biology 1978 - 1990 Research Officer Imperial Cancer Research Fund

研究领域

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Professor Jenny Southgate is Director of the Jack Birch Unit for Molecular Carcinogenesis (JBU) and holds a Research Chair funded externally by York Against Cancer. The research of the JBU focuses on human epithelial tissues and their cancers. Our aims are to understand the processes that control proliferation, differentiation and cellular organisation in normal and wounded epithelial tissues and how dysregulation of these processes leads to the development and progression of malignant disease. Most of the work in the Unit focuses on urothelium, the specialised epithelium that lines the urinary tract and gives rise to bladder cancer. A range of cell and tissue culture systems have been developed to study urothelial cells from normal and diseased tissues, and methods have been established using retroviruses to enable gene manipulation in order to recapitulate the early stages of neoplastic development. The capacity for in vitro-propagated normal human urothelial cells to undergo differentiation and form a functional urinary barrier has led to an interest in reconstructing urothelial cells into functional tissues for the purpose of tissue engineering and we are examining a range of natural and synthetic biomaterials as scaffolds for this purpose.