Pryor, Paul - York University - Department of Biology

个人简介

Paul Pryor is a newly appointed lecturer in the Centre for Immunology and Infection (CII) and HYMS. Paul obtained his BSc in Biochemistry from the University of York and then went on to do a PhD in Cell Biology in the laboratory of Professor Geoff Holman, University of Bath. Paul then undertook post-doctoral research in the laboratory of Professor J. Paul Luzio, University of Cambridge, researching the molecular mechanisms in delivery of material to lysosomes. In 2005 Paul was awarded a Wellcome Trust Career Development Fellowship and moved to the Department of Biology (York) in 2007, investigating phagolysosome biogenesis.

研究领域

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Host-pathogen interactions Phagocytosis Membrane traffic Lysosomes Phagolysosomes The Pryor lab is interested in the biogenesis of lysosomes and phagolysosomes. Lysosomes form part of our innate immunity, yet successful intracellular pathogens, such as Salmonella, Chlamydia and Mycobacteria, are able to manipulate the host's trafficking machinery to enable them to avoid/delay delivery to the lysosome and thereby create their replicative niche. We are using the yeast Saccharomyces cerevisiae to identify pathogen proteins that alter membrane trafficking. We then find the mammalian targets of these proteins using a variety of cell biological techniques such as proteomics, fluorescent microscopy, photo-crosslinking, immunoprecipiation and affinity chromatography. Identifying the mammalian targets of the pathogen proteins allows us to dissect how the pathogen can survive intracellularly.