研究领域

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In the early stages of infection, bacteria attach to host tissue. Interactions between host and bacterial proteins are also likely to play an important role in the maintenance and dissemination of infection. One aim of our research is to elucidate mechanisms of host-pathogen interactions. For example, the ability to bind the human protein fibronectin (Fn) is a characteristic that has been demonstrated for a number of pathogens. For Staphylococcus aureus, Fn-binding appears to play a role in infective endocarditis. S. aureus can also form difficult to eradicate aggregates, known as biofilms, on the surfaces of prosthetic devices such as mechanical heart valves. We are studying proteins involved in biofilm formation using techniques such as nuclear magnetic resonance spectroscopy, X-ray crystallography, isothermal titration calorimetry, surface plasmon resonance and multi-angle light scattering.

In the early stages of infection, bacteria attach to host tissue. Interactions between host and bacterial proteins are also likely to play an important role in the maintenance and dissemination of infection. One aim of our research is to elucidate mechanisms of host-pathogen interactions. For example, the ability to bind the human protein fibronectin (Fn) is a characteristic that has been demonstrated for a number of pathogens. For Staphylococcus aureus, Fn-binding appears to play a role in infective endocarditis. S. aureus can also form difficult to eradicate aggregates, known as biofilms, on the surfaces of prosthetic devices such as mechanical heart valves. We are studying proteins involved in biofilm formation using techniques such as nuclear magnetic resonance spectroscopy, X-ray crystallography, isothermal titration calorimetry, surface plasmon resonance and multi-angle light scattering.