Leake, Mark - York University - Department of Biology

个人简介

2013- Anniversary Chair of Biological Physics Depts of Physics and Biology, University of York 2007-2012 Royal Society University Research Fellow (URF) Dept of Physics, University of Oxford 2007-2012 Senior Research Fellow and PI in Systems Biology Dept of Biochemistry, University of Oxford 2008-2011 Hertford College Science Fellowship Hertford College, University of Oxford 2008 M.A. (Oxon) University of Oxford 2007-2009 PI, Interdisciplinary Research Collaboration in Bionanotechnology University of Oxford 2006-2007 Leverhulme Trust Early Career Fellow University of Oxford 2003-2006 Fellow, Interdisciplinary Research Collaboration in Bionanotechnology University of Oxford 2002-2003 DFG Postdoctoral Research Fellow Ruprect-Karls-Universität Heidelberg, Germany 2001-2002 Postdoctoral Research Fellow in Biological Physics University of Oxford 1997 M.A. (Cantab) University of Cambridge 1996-2001 Ph.D Biophysics University of London 1994-1995 M.Sc Medical Physics University of Surrey 1990-1993 B.A. Natural Sciences (Cantab) University of Cambridge

研究领域

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

I am the Anniversary Professorial Chair of Biological Physics, heading an interdisciplinary science team across the Depts of Physics and Biology. The group specializes in developing and applying novel forms of optical microscopy to investigate complex biological processes at the level of single molecules. Our research specializes on the theme of 'Single-molecule cellular biophysics'. This is becoming a highly topical area of life sciences research which strives to move towards a greater physiological relevance to single molecule biophysics experimentation, either by combining in vivo cellular biology techniques with those of cutting-edge single molecule biophysics or by creating a greater level of molecular complexity to single biomolecule experiments in vitro, and is in effect emerging as a novel disciple in its own right which is likely to increase in application significantly over the next few years as these techniques become more widely used. We use a range of cutting-edge biophotonics and photophysical methods in combination with state-of-the-art genetics. Our group has a depth of expertise in physics applied to biology at the single molecule level, and has worked on bio-molecule mechanical manipulation and force spectroscopy using both AFM and laser-tweezers, low-light fluorescence imaging in vivo and customized advanced microscope design involving development of nanometre length scale imaging with millisecond time resolution. We have a reputation in single molecule investigations on living cells involving several multi-institutional collaborations.