研究领域

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MicroRNA Biology The group studies microRNA-mediated silencing, a core molecular process required for mammalian cell development, homeostasis, and response to pathogenic and pathologic challenges. Currently, there are three main themes of research in the group: 1. MicroRNA-mediated silencing and the interplay between immunity and angiogenesis We investigate the role of microRNA-mediated silencing in the interaction between vasculature and immune cells in chronic disease and the effects of anti-angiogenic agents and immune checkpoint regulators on both systems. 2. Signal trandusction and microRNA-mediated silencing Our work aims to discover mechanisms that govern microRNA-mediated silencing. The group employs a wide range of approaches, from single molecule to whole organism, and from hypothesis-driven functional genomics and transcriptomics to computational biology techniques (see York Computational Immunology Lab), to dissect how the cross-talk between cell signalling cascades and the microRNA machinery determines cellular function. 3. MicroRNAs as diagnostic and prognostic disease biomarkers The group is developing pipelines that translate functional genomics into routine blood tests used for patient stratification and rational use of antibiotics and biologics.