Kaye, Paul - York University - Department of Biology

个人简介

Paul Kaye is Professor of Immunology and founding Director of the Centre for Immunology and Infection (CII). He obtained his undergraduate degree in Zoology from Imperial College in 1981 and his PhD in Immunology from University College London in 1984. At UCL, he studied the heterogeneity of antigen presenting cells, working in Prof. Sir Marc Feldmann's laboratory at the ICRF Tumor Immunology Unit. Paul then moved to the London School of Hygiene and Tropical Medicine for a post-doc with Jenefer Blackwell, examining how the macrophage natural resistance gene Nramp1 affected antigen presentation. Paul was appointed Lecturer in Immunology in 1988 and became Professor of Cellular Immunology and Head of the Immunology Unit in 1998. He joined the University of York and the Hull York Medical School (HYMS) in 2004, establishing the Immunology and Infection Unit, the predecessor to the CII. Paul is a Wellcome Trust Senior Investigator and in 2015 was elected as a Fellow of the Academy of Medical Sciences.

研究领域

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Antigen presentation Immunopathology Leishmaniasis Dendritic cells Imaging Inflammation Macrophages Paul's laboratory continues to focus on antigen presenting cells (APC), with a particular emphasis on the temporal and tissue-specific changes that occur in the APC compartment during the progression of inflammatory and infectious disease. Although experimental models of visceral leishmaniasis provide the major context in which these studies are performed, the laboratory has more recently introduced other infectious and non-infectious models to complement and extend these studies. Ongoing projects span fundamental research into macrophage and dendritic cell development, heterogeneity and function, and translational projects aimed at taking this knowledge forward for the development of new therapeutic tools and vaccines.