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个人简介

2017- Lecturer Department of Biology, University of York 2009-2016 Senior Research Fellow Research Department of Genetics, Evolution & Environment, Univesity College of London 2008-2009 Staff Scientist Population and Comparative Genomics Group Wellcome Trust Sanger Institute 2004-2008 Research Associate Population and Comparative Genomics Group, Wellcome Trust Sanger 2001 Postdoctoral Fellow Department of Evolutionary Biology, University of Copenhagen 2001 PhD (Plant Biology) Massey University, New Zealand 1994 BSc Honours (1st Class Biological Science) Massey University, New Zealand 1990 BSc (Botany) Victoria University of Wellington, New Zealand

研究领域

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We study evolutionary processes in genomes. We use this data to describe how genomes change, while maintaining the function of the molecular machinery of the cell and competing in a natural environment. We use a variety of laboratory and computational techniques, applying methods from molecular evolution, population genomics, comparative genomics, functional genomics (we also use also tinkering and plenty of thinking). We are open to exploring evolutionary genomics in a variety of species and timescales. Recent research Most recently we have been working with the fission yeast Schizosaccharomyces pombe as a model. We begun the process of describing the evolutionary history, genetic and phenotypic diversity of this model. Our aim is to describe how the genome and variations in the genome create the variation in the species. So far, we have described genomic diversity of all known wild strains, analysed more than 220 traits, described their heritability and conducted the first genome-wide association studies (GWAS) for this species (Nature Genetics 2015). We also showed these wild strains have potential in the winemaking industry. We then described structural variation in the genome (large duplications/deletions, inversions and translations).We showed that structural variants contribute considerably to heritable traits and some appear to be transient within populations (Nature Communications 2017).

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