研究领域

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Cell-cell signalling plays a critical role in establishing the pattern of the early vertebrate embryo. Fibroblast Growth Factor (FGF) peptide ligands have multiple roles in animal development, including early cell-type specification and patterning of the central nervous system. We use the amphibians Xenopus laevis and Xenopus tropicalis as models for our studies in early development. We have analyzed the function of a number targets of FGF signalling in amphibian development, including the Cdx genes, which code for a family of homeodomain transcription factors with roles in the development of all animals. We collaborate with Professor Peter Holland (Dept of Zoology, Oxford) in studying Cdx regulated pathways and their role in animal evolution.