Green, Allison - York University - Department of Biology

个人简介

Allison Green is a Senior Lecturer in Immunology. Previously she was Wellcome Senior Research Fellow in Basic Biomedical Science in the Centre for Immunology and Infection (CII) and HYMS and joined the Centre in 2010. She obtained her BSc in Immunology from Glasgow University (UK), a PhD in Virology, Immunology and Vaccination at St. Andrews University (UK) and then moved to Yale School of Medicine (USA) to conduct postdoctoral research in the laboratory of Richard Flavell. Whilst here, she obtained a Juvenile Diabetes Research (JDRF) Postdoctoral Fellowship, followed by a JDRF Career Development Award. In 2001, she was recruited to Cambridge University (UK) to set up her own laboratory funded by a Wellcome Trust/JDRF Career Development Award and subsequently a Wellcome Senior Research Fellowship in Basic Biomedical Science. In 2002, she was the first recipient of the GJ Thorbecke Award from the International Society for Leukocyte Biology in recognition of her work in inflammation and disease.

研究领域

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The Green Lab is interested in the mechanisms by which the immune system regulates autoaggressive cells that target and destroy host tissue. The autoimmune disease, Type 1 Diabetes in which the insulin producing beta cells in the islets of Langerhans are destroyed, is a particular focus. Using a series of transgenic and gene knockout models, we are deciphering the role of individual immune cells in the diabetic process in the hope of developing novel therapies to eradicate the disease. In addition, we are interested in identifying the key signal pathways that enable development of Foxp3+ regulatory T cells in the thymus and periphery as well as the mechanisms that control their survival and functionality in inflamed tissue.