Fogg, Paul C M - York University - Department of Biology

个人简介

2016 - Sir Henry Dale Fellow Department of Biology, University of York 2013 - 2016 Post-doc University of York 2012 - 2013 Post-doc University of Bristol 2009 - 2011 Research Fellow University of British Colombia, Vancouver 2008 - 2009 Post -doc University of Liverpool 2007 PhD University of Liverpool 2003 BSc University of Liverpool

研究领域

Rapid bacterial evolution is a major public health concern, and limiting the exchange of virulence or antimicrobial-resistance genes between bacteria is an acute challenge for modern medicine. My interest lies in the molecular mechanisms of horizontal gene transfer, in particular gene transfer agents (GTAs). GTAs are unusual viruses of bacteria with the potential to move any gene from one bacterium to another at extraordinary frequencies, yet there are huge gaps in our knowledge of GTA biology. My research aims to determine the fundamental mechanisms of GTA biology, their prevalence in pathogens and their impact on bacterial evolution.

近期论文

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Westbye, A. B., Leung, M. M., Florizone, S. M., Taylor, T. A., Johnson, J. A., Fogg, P. C. & Beatty, J. T. (2013) Phosphate concentration and the putative sensor kinase protein CckA modulate cell lysis and release of the Rhodobacter capsulatus gene transfer agent. J Bact. 195, 22, p. 5025-40. Fogg, P. C. M., Westbye, A. B. & Beatty, J. T. (2012) One for all or all for one: heterogeneous expression and host cell lysis are key to gene transfer agent activity in Rhodobacter capsulatus. PloS One. 7, 8, p. e43772.