Bryant, Nia - York University - Department of Biology

个人简介

2014 Chair of Cell Biology Department of Biology, University of York 2013 Professor of Molecular Cell Biology Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow 2010 - 2013 Reader Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow 2006 - 2010 Senior Lecturer, and Prize Fellow Lister Institute of Preventive Medicine (from 2004) Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow 2003 - 2006 Lecturer Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow 2002 - 2003 Research Fellow Garvan Institute of Medical Research, Sydney, Australia 1998 - 2002 Senior Research Officer Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. 1994 - 1998 Post Doctoral Fellow Institute of Molecular Biology, University of Oregon, Eugene, OR. U.S.A. 1992 - 1994 Temporary Lecturer Department of Biochemistry, University of Edinburgh 1993 Ph.D. in Biochemistry University of Edinburgh 1989 B.Sc. (Hons Biochemistry) Biological Sciences, University of Edinburgh

研究领域

Two interrelated areas: Regulation of SNARE-mediated membrane traffic Understanding the regulation of membrane traffic is an important goal in cell biology as this process underlies many physiological processes. We use a variety of systems, from yeast to mammalian cells, to study this. Insulin-regulated trafficking of GLUT4 Insulin increasing the rate of glucose transport into fat and muscle by delivering the facilitative glucose transporter GLUT4 from intracellular stores to the cell surface. This regulated membrane trafficking process is defective in the disease state of Type-2 diabetes. We aim to define the molecular mechanisms that regulate GLUT4-trafficking in fat and muscle cells.

近期论文

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Shewan, A.M., McCann, R.K., Lamb, C.A., Stirrat, L., Kioumourtzoglou, D., Adamson, I.S., Verma, S., James, D.E. and Bryant, N.J. (2013) Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells. J Cell Sci. 126, 1576-1582. Coonrod, E.M., Graham, L.A., Carpp, L.N., Carr, T.M., Stirrat, L. Bowers, K, Bryant, N.J. and Stevens, T.H. (2013) Homotypic Vacuole Fusion in Yeast Requires Organelle Acidification and not the V- ATPase Membrane domain. Dev. Cell. 27, 462-468.