Bruce, Neil C - York University - Department of Biology

个人简介

2002- Professor of Biotechnology Department of Biology, University of York 2001 - 2002 Reader in Biotechnology University of Cambridge 1991 - 2002 Staff Fellow, Tutor and Director of Studies for Natural Sciences (Biological) Trinity Hall, Cambridge 1990 - 2001 University Lecturer Institute of Biotechnology, University of Cambridge 1988 - 1991 Research Fellow Wolfson College, Cambridge 1987 PhD University of Kent 1986 - 1990 Postdoctoral Research Associate Institute of Biotechnology, University of Cambridge 1983 BSc Applied Biology Hatfield Polytechnic

研究领域

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The major research themes of our laboratory are microbial metabolism, biocatalysis and environmental biotechnology. A primary goal is to understand how microorganisms have adapted to utilise xenobiotic compounds as carbon and nitrogen sources for growth. The enzymes mediating these pathways often have potential commercial applications as recognition components in biosensors, as biocatalysts for synthetic chemistry, for the production of biofuels and for the bioremediation of soil and ground water. We are now engaged in extensive structural analysis of a number of these enzymes using X-ray crystallography. Work is also focusing on generating carefully designed mutant forms of a number of these enzymes to understand their catalytic mechanisms. A principal theme of our research is the biodegradation, biotransformation and phytoremediation of explosives.