个人简介

Education Ph. D. Chemistry, California Institute of Technology June, 2001(Graduate Advisor: Prof. Ahmed H. Zewail) B. S. Chemistry, KAIST(Korea Advanced Institute of Science and Technology) February, 1994 Graduated with highest honor (2nd out of 550 graduates) Career · Professor, Department of Chemistry, KAIST 2009 - present · Associate Professor, Department of Chemistry, KAIST 2006 - 2009 · Assistant Professor, Department of Chemistry, KAIST 2003 - 2006 · Group Leader, Center for Nano-materials & Chemical Reactions 2012 - present (Institute for Basic Science) · Director, Center for Time-Resolved Diffraction 2007 - 2012 (National Creative Research Initiatives by MOST/KOSEF) · Postdoctoral Scholar (Prof. K. Moffat) 2001 - 2003 Department of Biochemistry &Molecular Biology, University of Chicago · Postdoctoral Scholar (Prof. A. H. Zewail) 2001 Department of Chemistry, California Institute of Technology · Graduate Research Assistant (Prof. A. H. Zewail) 1994 - 2001 Department of Chemistry, California Institute of Technology Research Advisor: Prof. A. H. Zewail Research Collaborator: Prof. W. A. Goddard, III Academes and Society · American Crystallographic Association 2008 - present · American Association for the Advancement of Science 1998 - present · American Physical Society 1996 - present · American Chemical Society 1994 - present Awards · Morino Lectureship Award (MEST) 2011 · Best Lecturer Award (KAIST Chemistry Department) 2010 · Lectureship Award from Chemical Society of Japan 2009 · KAIST Teaching Excellence Award 2009 · KAIST Teaching Excellence Award 2008 · Best Oral Paper at 10th Eurasia Conference on Chemical Sciences 2008 · Best Lecturer Award (KAIST Chemistry Department) 2006 · 10th Young Scientist Award (MOST/KIAS) 2006 · 16th KOFST Best Paper Award 2006 · KAIST Academic Excellence Award 2006 · Damon Runyon Cancer Research Fellow 2002 - 2003 · Graduated with highest honors from KAIST 1994

研究领域

Physical Chemistry and Biophysics

One of the most fundamental questions in biology, chemistry, and physics is how the molecules interact, so called, reaction mechanisms. Our laboratory strives to understand the reaction mechanisms in molecular detail in gas phase, solution phase, and solid phase spanning amorphous phase, polycrystalline and single crystals. Traditionally, femtosecond spectroscopy has been used to achieve this goal, however, spectroscopic data, in most cases, fail to provide direct information on the structural changes such as bond lengths and bond angles. To remedy this, we combine the traditional femtoscience with direct structural tools such as diffraction, EXAFS, and NMR. These techniques can be applied to a wide range of systems, encompassing small molecules, nano-scale complexes, and macromolecules such as polymers, proteins and DNA. A typical experiment is conducted in a pump-probe manner; an optical pulse such as femtosecond laser pulse is directed to the sample of interest to initiate a desired reaction, and after a well-defined time delay, a probing pulse such as an ultrashort x-ray pulse is sent to the sample undergoing a reaction. Then, the signal resulted from the interaction of the reacting system and the probing pulse captures the molecular actions in real time. Since the measured signal (in this case, diffraction signal) is a function of molecular structures, the time-dependant data at various time delays contains a clue to the molecular reaction mechanisms and a novel data analysis of the time-resolved signal finally reveals the mechanism. Research topics · Molecular structural Dynamics · Chemical Reaction Dynamics · Protein structural Dynamics · Ultrafast X-ray Diffraction · Ultrafast Electron Diffraction · Ultrafast spectroscopy

近期论文

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"Direct observation of bond formation in solution with femtosecond X-ray scattering", K. H. Kim, J. G. Kim, S. Nozawa, T. Sato, K. Y. Oang, T. W. Kim, H. Ki, J. Jo, S. Park, C. Song, T. Sato, K. Ogawa, T. Togashi, K. Tono, M. Yabashi, T. Ishikawa, J. Kim, R. Ryoo, J. Kim, H. Ihee*, S.-i. Adachi*, Nature, 518, 385-389 (2015) (Online publication: 2015-02-18) "Implicit vs. Explicit Solvent Models for Calculating X-ray Solution Scattering Curves", P. Ganesan, J. G. Kim, J. H. Lee, J. Kim, H. Ihee*, Bull. Korean Chem. Soc., 35 (2014) (Accepted for publication). "Sub-100-ps Structural Dynamics of Horse Heart Myoglobin Probed by Time-resolved X-ray Solution Scattering", K. Y. Oang, K. H. Kim, J. Jo, Y. Kim, J. G. Kim, T. W. Kim, S. Jun, J. Kim, H. Ihee*, Chem. Phys., 442, 137-142 (2014) (Online publication: 2014-10-17) "Coherent Oscillations in Chlorosome Elucidated by Two-Dimensional Electronic Spectroscopy", S. Jun, C. Yang, M. Isaji, H. Tamiaki, J. Kim*, H. Ihee*, J. Phys. Chem. Lett., 5, 1386-1392 (2014) (Online publication: 2014-04-01) "Random-Graft Polymer-Directed Synthesis of Inorganic Mesostructures with Ultrathin Frameworks", C. Jo, Y. Seo, K. Cho, J. Kim, H. S. Shin, M. Lee, J.-C. Kim, S. O. Kim, J. Y. Lee, H. Ihee, R. Ryoo*, Angew. Chem. Int. Ed., 53, 5117-5121 (2014) (Online publication: 2014-04-01) "Reply to 'Contradictions in X-ray structures of intermediates in the photocycle of photoactive yellow protein'", Y. O. Jung, J. H. Lee, J. Kim, M. Schmidt, K. Moffat, V. Srajer, H. Ihee*, Nature Chemistry, 6, 259-260 (2014) (Online publication: 2014-03-21) "Anti-counterfeit nanoscale fingerprints based on randomly distributed nanowires", J. Kim, J. M. Yun, J. Jung, H. Song, J.-B. Kim, H. Ihee*, Nanotechnology, 25, 155303 (2014) (Online publication: 2014-03-20) "Ultrafast Energy Transfer in Chlorosome Probed by Femtosecond Pump-Probe Polarization Anisotropy", S. Jun, T. W. Kim, C. Yang, M. Isaji, H. Tamiaki, H. Ihee*, J. Kim*, Bull. Korean Chem. Soc., 35, 703-704 (2014) (Online publication: 2014-03-20) "Pump-Probe X-ray Solution Scattering Reveals Accelerated Folding of Cytochrome c upon Suppression of Misligation", T. W. Kim, J. G. Kim, C. Yang, H. Ki, J. Jo, H. Ihee*, Bull. Korean Chem. Soc., 35, 697-698 (2014) (Online publication: 2014-03-20) "Conformational Substates of Myoglobin Intermediate Resolved by Picosecond X-ray Solution Scattering", K. Y. Oang, J. G. Kim, C. Yang, T. W. Kim, Y. Kim, K. H. Kim, J. Kim, H. Ihee*, J. Phys. Chem. Lett., 5, 804-808 (2014) (Online publication: 2014-02-13) "Molecular reaction and solvation visualized by time-resolved X-ray solution scattering: Structure, dynamics, and their solvent dependence", K. H. Kim, J. Kim, J. H. Lee, H. Ihee*, Struct. Dyn., 1, 011301 (2014) (Online publication: 2014-02-11) "Protein energy landscapes determined by five-dimensional crystallography", M. Schmidt*, V. Srajer, R. Henning, H. Ihee, N. Purwar, J. Tenboer, S. Tripathi, Acta Cryst. D, 69, 2534-2542 (2013) (Online publication: 2013-11-19) "Conjugated organic framework with three-dimensionally ordered stable structure and delocalized π clouds", J. Guo, Y. Xu, S. Jin, L. Chen, T. Kaji, Y. Honsho, M. A. Addicoat, J. Kim, A. Saeki, H. Ihee, S. Seki, S. Irle, M. Hiramoto, J. Gao & D. Jiang*, Nature Commun., 4, 2736 (2013) (Online publication: 2013-11-13) "Prospect of Retrieving Vibrational Wave Function by Single-Object Scattering Sampling", H. Ki, K. H. Kim, J. Kim, J. H. Lee, J. Kim, H. Ihee*, J. Phys. Chem. Lett., 4, 3345-3350 (2013) (Online publication: 2013-10-03) "Global reaction pathways in the photodissociation of I3- ion in solution at 267 nm and 400 nm studied by picosecond X-ray liquidography", K. H. Kim, H. Ki, K. Y. Oang, S. Nozawa, T. Sato, J. Kim, T. K. Kim, J. Kim, S. Adachi, H. Ihee*, ChemPhysChem, 14, 3687-3697 (2013) (Online publication: 2013-10-02) "Correlation between Functionality Preference of Ru Carbenes and Exo/Endo Product Selectivity for Clarifying the Mechanism of Ring-Closing Enyne Metathesis", O. S. Lee, K. H. Kim, J. Kim, K. Kwon, T. Ok, H. Ihee*, H.-Y. Lee*, J.-H. Sohn*, J. Org. Chem., 78, 8242-8249 (2013) "High-throughput instant quantification of protein expression and purity based on photoactive yellow protein turn off/on label", Y. Kim, P. Ganesan, H. Ihee*, Protein Sci., 22, 1109-1117 (2013) (Online publication: 2013-06-05) "Multireference Ab Initio Study of the Ground and Low-Lying Excited States of Cr(CO)2 and Cr(CO)3", J. Kim*, J. Kim, H. Ihee*, J. Phys. Chem. A, 117, 3861-3868 (2013) (Online publication: 2013-04-15) "Solvent-Dependent Molecular Structure of Ionic Species Directly Measured by Ultrafast X-Ray Solution Scattering", K. H. Kim, J. H. Lee, J. Kim, S. Nozawa, T. Sato, A. Tomita, K. Ichiyanagi, H. Ki, J. Kim, S. Adachi*, H. Ihee*, Phys. Rev. Lett., 110, 165505 (2013) (Online publication: 2013-04-18) "Volume-conserving trans-cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography", Y. O. Jung, J. H. Lee, J. Kim, M. Schmidt, K. Moffat, V. Srajer, H. Ihee*, Nature Chemistry, 5, 212-220 (2013) (Online publication: 2013-02-03)