Nevado, Cristina - University of Zurich

个人简介

Cristina Nevado graduated in Chemistry at the Autónoma University in 2000. In October 2004 she received her PhD from the same university working with Prof. Antonio M. Echavarren thereafter joining the group of Prof. Alois Fürstner at the Max-Planck-Institut für Kohlenforschung (Germany) as a post doctoral associate. In May 2007 she started her independent career as an Assistant Professor of Organic Chemistry at the University of Zürich. In 2011, Cristina was awarded the Chemical Society Reviews Emerging Investigator Award and the Thieme Chemistry Journal Award in recognition of her contributions in the field of synthetic organic chemistry. In 2012 she received an ERC Junior Investigator grant and in 2013 was awarded the Werner Prize of the Swiss Chemical Society and was directly promoted to Full Professor. In 2019, she received the Royal Society of Chemistry Award in Organometallic Chemistry and in 2020 the Excellence Research Trajectory Award of the Royal Spanish Chemical Society (RSEQ) as well as the Margaret Faul Women in Chemistry Award. Among her many contributing roles to the community, Cristina is currently Senior Associate Editor for ACS Central Science, Organic Syntheses and Science of Synthesis. Rooted in the wide area of organic chemistry, her research program is focused on complex chemical synthesis and new organometallic reactions.

研究领域

Organic synthesis lies at the core of every advanced technology in our modern world: first, providing substances for further development and usage for other disciplines but also delivering previously unprecedented scaffolds. As the construction of complex molecular architectures from chemical building blocks still remains a far-from-routine task, the discovery of methodologies to increase the control over reactivity, while achieving molecular complexity with high levels of efficiency, is still one of the frontier challenges of chemistry in the 21st century. Our group aims to develop a multidisciplinary research program supported on three pillars: first, the development of new processes for the construction of C-C and C-X bonds based on late-transition metal catalysis; second, the implementation of such methods to streamline the synthesis of complex natural products. A third focus is the study at a molecular level, both computational and experimentally, of relevant biological processes influenced by these advanced organic molecules such as cancer progression, cancer metastasis and cell motility. Our main contributions to each of these fields are summarized below. Design - Method Development Synthesis - Natural Products In Silico - Drug Design Medchem

近期论文

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Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C–H bond activation. X. Hu, I. Cheng-Sánchez, W. Kong, G. A. Molander, C. Nevado* doi.org/10.1038/s41929-024-01153-0 (P^N^C) Ligands to Stabilize Gold(III): A Straightforward Access to Hydroxo, Formate, and Hydride Complexes J. Martín, J. Schörgenhumer, M. Biedrzycki, C. Nevado* Inorg. Chem. (2024), 63, 8390–8396 Asymmetric, Remote C(sp3)−H Arylation via Sulfinyl-Smiles Rearrangement. Y. Hu, C. Hervieu, E. Merino*, C. Nevado* Angew. Chem.Int. Ed.(2024), e20231915 Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain I. Cheng-Sánchez, K. A. Gosselé, L. Palaferri, M. S. Kirillova, C. Nevado* doi.org/10.1021/acsmedchemlett.3c00490 Dual Nickel/Photoredox-Catalyzed Asymmetric Carbamoylation of Benzylic C(sp3)-H Bonds S. Cuesta-Galisteo, J. Schoergenhumer, C. Hervieu, C. Nevado* Angew. Chem. Int. Ed. (2024), e202313717 Chiral arylsulfinylamides as reagents for visible light-mediated asymmetric alkene aminoarylations C.Hervieu, M. S. Kirillova, Y. Hu, S. Cuesta-Galisteo, E. Merino*, C. Nevado* doi.org/10.1038/s41557-023-01414-8 Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes X. Du, I. Cheng-Sánchez, C. Nevado* J. Am. Chem. Soc. (2023), 145, 12532−12540 Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides X. Hu, I. Cheng-Sánchez, S. Cuesta-Galisteo, C. Nevado* J. Am. Chem. Soc. (2023), 145, 6270–6279 Synthesis of Cyclometalated Gold(III) Complexes via Catalytic Rhodium to Gold(III) Transmetalation J. Martín, E. Gómez-Bengoa, A. Genoux, C. Nevado* Angew. Chem. Int. Ed. (2022), e202116755 Chelation-assisted C–C bond activation of biphenylene by gold(i) halides H. Beucher, J. Schörgenhumer, E. Merino, C. Nevado* Chem. Sci. (2021),12, 15084-15089 Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres C. Hervieu, M. S. Kirillova, T. Suárez, M. Müller, E. Merino*, C. Nevado* Nat. Chem. (2021), 13, 327-334 Diaryl Ether Formation Merging Photoredox and Nickel Catalysis L. Liu, C. Nevado* Organometallics. (2021), 40, 2188–2193 Synthesis and Characterization of Bidentate (P^N)Gold(III) Fluoride Complexes: Reactivity Platforms for Reductive Elimination Studies A. Genoux, M. Biedrzycki, E. Merino, E. Rivera, A. Linden, C. Nevado* Angew. Chem. Int. Ed. (2021), 60, 4164-4168 Nickel‐Catalyzed Asymmetric Synthesis of α‐Arylbenzamides S. Cuesta-Galisteo, J. Schörgenhumer, X. Wei, E. Merino, C. Nevado* Angew. Chem. Int. Ed. (2021), 60, 1605–1609 Phosphorescent k3‐(N^C^C)‐Gold(III) Complexes: Synthesis, Photophysics, Computational Studies and Application to Solution‐Processable OLEDs H. Beucher, S. Kumar, R. Kumar, E. Merino, W.-H. Hu, G. Stemmler, S. Cuesta-Galisteo, J. A. Gonzalez, L. Bezinge, J. Jagielski, C.-J. Shih*, C. Nevado* Chem. Eur. J. (2020), 26, 17604–17612 [C^N]‐Alkenyl Gold(III) Complexes by Proximal Ring‐Opening of (2‐Pyridyl)alkylidenecyclopropanes: Mechanistic Insights J. A. González, F. Verdugo, J. L. Mascareñas, F. López, C. Nevado* Angew. Chem. Int. Ed. (2020), 59, 20049–20054 Mechanistic Insights into C(sp2)−C(sp)N Reductive Elimination from Gold(III) Cyanide Complexes A. Genoux, J. A. González, E. Merino, C. Nevado* Angew. Chem. Int. Ed. (2020), 59, 2–8 Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers A. Dolbois, L. Batiste, L. Wiedmer, J. Dong, M. Brütsch, D. Huang, N. M. Deerain, D. Spiliotopoulos, I. Cheng-Sánchez, E. Laul, C. Nevado*, P. Śledź*, A. Caflisch* ACS Med. Chem. Lett. (2020), 11, 1573–1580 Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling X. Wei, W. Shu, A. García-Domínguez, E. Merino, C. Nevado* J. Am. Chem. Soc. (2020), 142, 13515–13522 Understanding the Mechanism of Action of Pyrrolo[3,2-b]quinoxaline-derivatives as Kinase Inhibitors A. Unzue, C. Jessen-Trefzer, D. Spiliotopoulos, E. Gaudio, C. Tarantelli, J. Dong, H. Zhao, J. Pachmayr, S. Zahler, E. Bernasconi, G. Sartori, L. Cascione, F. Bertoni*, P. Śledź, A. Caflisch*, C. Nevado* RSC Med. Chem. (2020), 11, 665-675 Highly Efficient Green Solution Processable OLEDs Based on a Phosphorescent Κ3-(N^C^C)Gold(III)-Alkynyl Complex H. Beucher, S. Kumar, E. Merino, W.-H. Hu, G. Stemmler, S. Cuesta-Galisteo, J. A. González, J. Jagielski, C.-J. Shih*, C. Nevado* Chem. Mater. (2020), 32, 1605–1611 Ni-Catalyzed Reductive Dicarbofunctionalization of Nonactivated Alkenes: Scope and Mechanistic Insights W. Shu, A. García-Domínguez, M. T. Quirós, R. Mondal, D. J. Cárdenas, C. Nevado* J. Am. Chem. Soc. (2019), 141, 13812-13821 Oxidant speciation and anionic ligand effects in the gold-catalyzed oxidative coupling of arenes and alkynes Manuel Hofer, Teresa de Haro, Enrique Gómez-Bengoa, Alexandre Genoux, Cristina Nevado* Chem. Sci. (2019),10, 8411-8420 Dual Photoredox/Nickel‐Catalyzed Three‐Component Carbofunctionalization of Alkenes A. García-Domínguez, R. Mondal, C. Nevado* Angew. Chem. Int. Ed. (2019), 58, 12286-12290 k3-(N^C^C)Gold(III) Carboxylates: Evidence for Decarbonylation Processes H. Beucher, E. Merino, A. Genoux, T. Fox, C. Nevado* Angew. Chem. Int. Ed. (2019), 58, 9064-9067 Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules J. Zhu, J. Dong, L. Batiste, A. Unzue, A. Dolbois, V. Pascanu, P. Sledz, C. Nevado*, A. Caflisch* ACS Med. Chem. Lett. (2018), 9, 929-934 Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes W. Shu, E. Merino, C. Nevado* ACS Catalysis (2018), 8, 6401-6406 Transforming Olefins into Dinucleophiles A. García-Domínguez, C. Nevado* Chimia (2018), 72, 212-215 Structural Analysis of Small Molecule Binding to the BAZ2A and BAZ2B Bromodomains A. D. Vedove, D. Spiliotopoulos, V. G. D´Agostino, J. R. Marchand, A. Unzue, C. Nevado, G. Lolli*, A. Caflisch* ChemMedChem (2018), 13,1479 –1487 Iriomoteolides: Novel Chemical Tools to Study Actin Dynamics A. Unzue, R. CribiÙ, M. M. Hoffman, T. Knehans, K. Lafleur, A. Caflisch*, C. Nevado* Chem. Sci. (2018), 9, 3793-3802 Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple) L. Batiste, A. Unzue, A. Dolbois, F. Hassler, X. Wang, N. Deerain, J. Zhu, D. Spiliotopoulos, C. Nevado*, A. Caflisch* ACS Cent. Sci., (2018), 4, 180–188 Gold-catalyzed oxidative aminoesterification of unactivated alkenes P. Feige, T. de Haro, G. Rusconi, E. Merino, C. Nevado*Monatsh. Chem. (2018), 149, 749-754